Biological Sciences
Master: José Quintans, BSLC 300, 702-7964, qui4@midway.uchicago.edu
Senior Adviser: Manfred D. E. Ruddat, HM 261, 702-8623, mruddat@uchicago.edu
Administrative Assistant: Kila Roberts, BSLC 328, 702-7962, kila@uchicago.edu
Laboratory Manager: Marcia A. Gilliland-Roberts, BSLC 336, 702-1930, mroberts@yoda.bsd.uchicago.edu
Staff Secretary: Lora Evans, BSLC 301, 702-7963, levans@midway.uchicago.edu
Administrator, Howard Hughes Medical Institute Programs:
Patrick Medina, BSLC 303, 834-7744, medina@uchicago.edu
Faculty Advisers:
Martin Feder, Organismal Biology & Anatomy, A 201, 702-8096;
Gayle Lamppa, Molecular Genetics & Cell Biology, CLSC 827A,
702-9837;
Manfred D. E. Ruddat, Ecology & Evolution, HM 261, 702-8623;
Marvin W. Makinen, Biochemistry & Molecular Biology, CLSC 439B, 702-1080;
Phillip Lloyd, Neuroscience Specialization, SBRI J45, 702-6376;
Bana Jabri, Immunology Specialization, AMB S352;
Olaf Schneewind, Microbiology Specialization, CLSC 601, 834-9060;
Carole Ober, Genetics, CLSC 507C, 834-0735
Undergraduate Research and Honors: Deborah J. Nelson, Ab 506A,
702-0126, dnelson@drugs.uchicago.edu
Summer Undergraduate Research: Paul Strieleman, BLSC 338, 702-5076, pstriele@midway.uchicago.edu
Program of Study
Biology is the study of living things and their adaptations to the pressures of natural selection. The faculty of the College believes that a sound knowledge of biology is essential for understanding many of the most pressing problems of modern life and for intelligent involvement in their eventual solution. The Biological Sciences Collegiate Division, therefore, provides a variety of general education courses for all College students--prospective biologists and nonbiologists alike. Although most of the course offerings beyond the introductory year are designed to serve the needs of students majoring in biological sciences, many of these courses are well suited to students in other areas who wish to study some aspect of modern biology in greater detail. Courses on the ethical and societal implications of the biological sciences, for example, are of interest to all students.
The General Education Requirement
in the Biological Sciences
Students choose one of the following options to meet the general education requirement for the biological sciences:
1. an integrated Natural Sciences or Environmental Sciences sequence for nonmajors, covering all general education requirements in the physical and biological sciences; or
2. a two-quarter general education sequence for nonmajors; or
3. a Fundamentals Sequence required for students majoring in biological sciences and students preparing for the health professions.
Advanced Placement Credit. For students who do not plan to major in the biological sciences or prepare for the health professions, a score of 4 or 5 on the AP biology test confers credit for BIOS 10110. These students complete the general education requirement with either one or two topics courses in the biological sciences.
If they complete an AP 5 Fundamentals Sequence students with a score of 5 on the AP biology test will be awarded a total of two quarters of credit for the general education requirement. This option is especially appropriate for students who plan to major in the biological sciences or prepare for the health professions, but it is open to all qualified students.
Biological Sciences Writing Program. The Biological Sciences Writing Program is designed to assist both professors and students in biological sciences courses that are reading and writing intensive, using teaching assistants with both science- and humanities-based backgrounds to conduct writing workshops and discussion sections.
Requirements for the Biological Sciences Major
The goals of the biological sciences program are to give students (1) an understanding of currently accepted concepts in biology and the experimental support for these concepts, and (2) an appreciation of the gaps in our current understanding and the opportunities for new research in this field. Emphasis is placed on introducing students to the diversity of subject matter and methods of investigation in the biological sciences. The program prepares students for graduate or professional study in the biological sciences and for careers in the biological sciences.
General Education Courses for Biological Sciences Majors
To prepare for more advanced work in the biological sciences, students must take CHEM 11101-11201/11102-11202 (or equivalent) to meet the general education requirement in physical sciences; MATH 13100-13200 or higher to meet the mathematics requirement in general education; and two courses in a Fundamentals Sequence (BIOS 20181-20182 or 20191-20192) to meet the general education requirement in biological sciences. Students with a score of 5 on the AP biology test may use their AP credit to meet the general education requirement in biological sciences if the AP 5 sequence is completed.
Courses Required for the Biological Sciences Major
Courses in the Physical Sciences Collegiate Division
Biological sciences majors must complete the third quarter of general chemistry (CHEM 11301/11302 or equivalent); two quarters of organic chemistry (CHEM 22000-22100/23100); two quarters of physics (PHYS 12100-12200 or higher); one additional quarter of calculus (MATH 13300 or higher), biomathematics (MATH 21400), or statistics (STAT 22000); and one additional course in mathematics, statistics (22000 or higher), CHEM 22200/23200, PHYS 12300 or higher, or approved 20000-level physical science course.
Courses in the Biological Sciences
Fundamentals Sequence. Students register for the final three quarters of their Fundamentals Sequence (BIOS 20180s or 20190s) in the major, or for the two-quarter AP 5 Fundamentals Sequence if they have a 5 on the AP biology test.
20200-level and above Biological Sciences Courses. Students also register for Introduction to Biochemistry (BIOS 20200) plus five additional 20200-level and above courses in biological sciences. These five courses are selected by the student unless the student chooses to complete a "specialization," in which case three courses are stipulated by the specialization (see below).
NOTE: BIOS 00199, 00206, and 00299 may not be used to meet the requirements of the major. In most cases, courses listed under the heading "Specialized Courses" may not be used to meet the requirements of the major. Limited exceptions are specifically noted.
Summary of Requirements
General CHEM 11101-11201/11102-11202 or equivalent*
Education MATH 13100-13200, 15100-15200, or 16100-16200*
BIOS 20181-20182 or BIOS 20191-20192 or a 5 on the AP biology test if an AP 5 sequence is completed.
Major 2-3 BIOS 20239** and one additional AP 5 sequence course (2) or completion of BIOS 20180s or 20190s (3)
1 CHEM 11301/11302 or equivalent*
1 BIOS 20200 (Biochemistry)
5 biological
sciences courses above 20200
(may include BIOS 00298)
2 CHEM 22000-22100/23100
2 PHYS 12100-12200 or higher*
1 MATH 13300, 15300, or 16300, or STAT 22000* or MATH 21400**
1 additional
course in mathematics (including MATH 21400 or 21500), statistics (22000
or higher), CHEM 22200/23200, PHYS 12300 or higher, or approved 20000-level
physical science course
15-16
* Credit may be granted by examination.
** Open only to students with a 5 on the AP biology test.
Grading. Students must receive quality grades in all courses in the major.
Research Opportunities. Students are encouraged to carry out individual guided research in an area of their interest. A student may propose an arrangement with any faculty member in the Biological Sciences Collegiate Division to sponsor and supervise research on an individual tutorial basis. Students register for BIOS 00199 or 00299 for course credit. Consult the course description section for information about procedures, grading, and requirements for registration in BIOS 00199 and 00299.
Some financial support may be available to students with third- or fourth-year standing for summer research through their research supervisors or through fellowships awarded competitively by the Biological Sciences Collegiate Division.
Honors in Biological Sciences. Students may earn a bachelor's degree with honors in the biological sciences by satisfactorily completing an individual research program and honors thesis. To be eligible for honors, students must also have a GPA of 3.25 or higher overall and in courses in the based on all course work up to the final quarter of graduation. Students are urged to consult with their advisers and with the director of the honors program well before their senior year for guidance on meeting the requirements for honors.
Honors students rarely begin their research later than the summer before their senior year; most honors students begin research in their junior year or earlier. Fourth-year students usually complete BIOS 00299 during Autumn and Winter Quarters and must complete BIOS 00298 in Spring Quarter. Students prepare oral and visual presentations of their research for a poster session early in Spring Quarter. Fourth-year students who wish to be considered for honors must submit a first draft of their thesis before the end of third week of Spring Quarter; it will be evaluated by two reviewers and returned to them with comments. The final version will then be due at the end of eighth week, and must be approved by the director of the honors program in consultation with the reviewers.
Specialization Programs in the Biological Sciences
Students who wish to complete a "specialization" should discuss their plans with the specialization chair in Spring Quarter of their second year.
Specialization in Cellular and Molecular Biology. Biological sciences majors who meet the following requirements will be recognized as having completed a specialization in the area of cellular and molecular biology.
The following requirements must be met:
Courses 1. third quarter of organic chemistry (CHEM 22200/23200)
2. three of the five 20200-level courses in the biological sciences that are required for the biological sciences major must be completed within the specialization, with one course each from three of the four following areas being selected:
a. BIOS
21207. Cell Biology
b. BIOS 21226. Genetics
c. BIOS 21227 or 23299. Developmental Biology
d. BIOS 21208 or 21209. Molecular Biology
Laboratory completion of an independent research project that
Research either:
1. qualifies as a senior honors project; or
2. is approved by the director of the specialization.
The specialization in cellular and molecular biology is administered by the Department of Molecular Genetics and Cell Biology. For more information, consult Gayle Lamppa (702-9837, gklamppa@midway.uchicago.edu).
Specialization in Ecology and Evolution. Biological sciences majors who complete the course work indicated below and meet the requirements of the senior honors paper will be recognized as having completed a specialization in ecology and evolution. This specialization is recommended for students who are interested in pursuing graduate work in the field or in laboratory sciences of ecology, evolution, population genetics, or behavior. Based on the student's particular interest, he or she will elect a faculty adviser, who then may recommend specific courses necessary to meet the specialization requirements (see following section). The faculty adviser may also help the student find an appropriate research laboratory in which to conduct an individual research project.
The following requirements must be met:
Courses 1. three quarters of calculus and three quarters of statistics (starting at the level of STAT 22000) in lieu of the physics requirement
2. three upper-level courses in the biological sciences,
as recommended by the faculty adviser or the faculty member in whose lab the student does his/her research, from a menu of courses in ecology, evolution, genetics, or behavior
Laboratory completion of original research in the laboratory under
or Field the guidance of a member of the ecology and evolution
Research faculty, which will qualify the student to write an honors paper. NOTE: Field research must be completed by the end of the growing season (summer) of the third year.
The specialization in ecology and evolution is administered by the Department of Ecology and Evolution. For more information, consult Manfred Ruddat (702-8796, mruddat@uchicago.edu).
Specialization in Immunology. Biological sciences majors who complete the following three courses will be recognized as having a specialization in immunology. For those who wish further study, an elective is available to provide an in-depth understanding of key general immunological questions. For more information, consult Bana Jabri, Assistant Professor, Department of Pathology and the Committee on Immunobiology (834-8670, bjabri@bsd.uchicago.edu).
Required Courses
BIOS 25256. Immunobiology (Autumn)
BIOS 25257. Advanced Immunology (Winter)
BIOS 25258. Immunopathology (Spring)
Elective Course
BIOS 25259. Fundamental Issues in Immunology (Autumn)
Specialization in Microbiology. Biological sciences majors who complete the following requirements will be recognized as having completed a specialization in microbiology. Students in this specialization are required to complete three quarters of organic chemistry. Students register for three core lecture courses in the specialization (BIOS 25206, 25216, and 25286), plus a laboratory requirement (BIOS 25210). Several electives are available to provide additional training in microbiology. With prior approval from the specialization chair, it may be possible to substitute one course from the list of suggested electives for one of the core courses. For more information, students should consult with Olaf Schneewind, chairman of the Committee on Microbiology (834-9060, oschneewind@delphi.bsd.uchicago.edu), or with Dominique Missiakas, undergraduate adviser of the Committee on Microbiology (834-8161, dmissiak@bsd.uchicago.edu).
Core Lecture Courses
BIOS 25206. Introduction to Bacterial Physiology (Autumn)
BIOS 25216. Molecular Genetic Analysis of Bacterial Pathogenesis
(Spring)
BIOS 25286. Viruses of Eukaryotes (Spring)
Laboratory Requirement
BIOS 25210. Experimental Physiology of Bacteria (Winter)
Electives in the Committee on Microbiology
BIOS 21307. Bacterial Genomes (Spring)
BIOS 25307. Molecular Genetic Analysis of Bacteriophage (Spring)
Honors Program in the Microbiology Specialization. Students who complete a research thesis have an opportunity to receive rigorous advanced training in microbiology and receive honors. To graduate with honors in the biological sciences with a specialization in microbiology, students are required to (1) maintain a GPA of 3.25 or higher both overall and in the major, and (2) meet the lecture and laboratory course requirements of the specialization with a GPA of 3.25 or higher. They must also register for two research/reading courses (see below) and complete an experimental honors thesis project based on an experimental report covering at least two quarters of work in the laboratory of a faculty member of the Committee on Microbiology. The honors thesis paper and progress of the honors student in the final (fourth) year of study will be evaluated by a Committee of three faculty members assembled by the Chair of the Committee on Microbiology. Students interested in a research thesis should discuss their plans with the committee chair and enroll in 00199 (Undergraduate Research, Autumn Quarter), 00299 (Advanced Research in the Biological Sciences, Winter Quarter), and 00298 (Undergraduate Research Seminar, Spring Quarter).
Specialization in Neuroscience. Biological sciences majors who complete the three required courses listed below will be recognized as having completed a specialization in neuroscience. Students who elect to specialize should consult the faculty adviser, Kamal Sharma, who is available to advise on the choice of classes and to help identify laboratories in which individual research projects can be carried out. Students who plan to specialize are encouraged to begin the required sequence below in Spring Quarter of their second year, carry out individual guided research, participate in the honors research program, and attend seminars related to neurobiology/ biopsychology. The required courses are:
BIOS 24204. Cellular Neurobiology
BIOS 24205. Systems Neuroscience
BIOS 24214. Cognitive Neuroscience
The following courses deal with topics of interest to neuroscientists. Students specializing in neuroscience may use these courses as electives to meet requirements for the major. Please note that the psychology courses meet requirements for the major only for students specializing in neuroscience.
BIOS 24207. Developmental Neurobiology
BIOS 24211. Neuroethology
BIOS 24217. Conquest of Pain
BIOS 24218. Molecular Neurobiology
BIOS 24221. Computational Neuroscience
I:
Single Neuron Computation
BIOS 24222. Computational Neuroscience II: Vision
BIOS 24223. Computational Neuroscience III: Language
BIOS 29405. Mathematical and Statistical Methods for Neuroscience I
BIOS 29406. Mathematical and Statistical Methods for Neuroscience II
BIOS 29407. Mathematical and Statistical Methods for Neuroscience III
PSYC 31000. Perspectives in Drug Abuse
PSYC 32000. Color Vision
PSYC 35000. Physiology of Vision
PSYC 38000. Seminar: Memory and Learning
PSYC 38700. Connectionist Modeling: Techniques
STAT 24700. Introduction to Probability Models
Minor Program in Interdisciplinary Quantitative Studies
in the Natural Sciences
The minor in Interdisciplinary Quantitative Studies in the Natural Sciences offered by the Division of Biological Sciences is designed for third- and fourth-year majors in biology, chemistry, computer science, mathematics, and physics. The minor requires five courses: Computational Biology and four courses chosen from the list below.
Computational Biology, a course that carries 200 units of credit, introduces the interdisciplinary research and training expected of scientists in the twenty-first century. The other four required courses, which are chosen in consultation with the Master of the Biological Sciences Collegiate Division, allow students to pursue either a specific area of interest or a range of interests. Students are required to meet with the Master by the end of Spring Quarter of their third year to discuss a program of study. The Master's approval for the minor program should be submitted to a student's College adviser by Spring Quarter of his or her third year on a form obtained from the adviser.
No course in the minor can be double counted with the student's major(s), with other minors, or with general education requirements. More than half of the requirements for the minor must be met by registering for courses bearing University of Chicago course numbers.
In addition to registering for the required introductory course described above, students choose four courses from the following list, which is subject to change.
BIOS 21216. Introductory Statistical Genetics
BIOS 21316. Biological Chemistry
BIOS 21318. Molecular Biophysics
BIOS 21319. RRP: Ribosomes, RNA, and Protein
BIOS 22242. Biological Fluid Mechanics
BIOS 22243. Biomechanics of Organisms
BIOS 24211. Neuroethology
BIOS 24221-24223. Computational Neuroscience
BIOS 2640. Introduction to Bioinformatics
MATH 21400-21500. Biomathematics
Faculty
P. Amarasekare,
Y. Amit, C. Andrews, P. Ashton-Rickardt,
W. Barnhart, J. Bates,
A. Bendelac, J. Bergelson, S. Boyle-Vavra, M. Brady, K. Cagney, M. Casadaban,
L. Casalino, M. Caserta, B. Chernoff, Z. Chi, K.-S. Chiang, A. Chong, T.
Christianson,
M. Coates, C. Correll, N. Cox, J. Coyne,
J. Crispino, R. Daum, E. DeSombre, H. de Wit,
J. Dignam, A. DiRienzo, W. Du, V. Dukic, G. Dwyer, W. Epstein, R. Esposito,
M. E. Feder, E. Ferguson, B. Fineschi, J. Flynn,
M. Foote, A. Fox, G. Franzoso,
H. C. Friedmann, T. Gajewski, G. Getz, M. Giger, D. Gillen, B. Glick, J.
Goldberg,
L. Goldman, P. Goldstein, W. Green, J. Greenberg, G. Greene, E. Grove, M. Hale,
K. Hamann, D. Hanck, R. Haselkorn, N. Hatsopoulos, L. Heaney, A. Heller, R. Ho,
W. Hoff, R. Hudson, A. Hunter, N. Issa, D. Jablonski, B. Jabri, R. Josephs, M.
Kearney,
S. Kent, S. Koide, M. Kreitman, S. Kron, V. Kumar, M. LaBarbera, B. Lahn, G.
Lamppa,
E. Larsen, D. Lauderdale, C. Lese-Martin, W.-H. Li, Y. Li, S. Liao, A. Lin,
P. Lloyd, R. E. Lombard, M. Long, K. Macleod, P. Makovicky, D. Maestripieri,
A. Mahowald, M. W. Makinen, J. Malamy, D. Margoliash, S. Margulis, R. Martin,
T. E. Martin, P. Mason, J. Mateo, M. McClintock,
R. McCrea, J. McElwain, D. McGehee, S. C. Meredith, L. Mets, K. Millen, J.
Milton, D. Missiakas, A. Montag, J. Moss,
G. Mueller, P. Mueller, M. Musch,
J. Nachman, T. Nagylaki, D. Nelson, M. Nishimura,
A. Noronha, C. Ober, M. Osadjan, C. Palfrey, T. Pan, S. Patel, B. Patterson, I. Pavlova,
R. Perlman, M. Peter, C. Pfister,
J. Piccirilli, D. Preuss, T. Price, V. Prince, S. Pruett-Jones, J. Quintans, C.
Ragsdale, J.-M. Ramirez, P. Rathouz, T. Regier, P. Rice, B. Roizman,
M. Rosner, L. F. Ross, L. Rothman-Denes,
M. D. E. Ruddat, U. Schmidt-Ott,
O. Schneewind, C. Schonbaum, M. Schreiber, P. Schumacker, J. Schwab, E. Schwartz,
P. Sereno, J. Shapiro, K. Sharma,
N. Shubin, P. Sierwald, H. Singh, S. Sisodia, T. Sosnick, A. Sperling, J.
Staley, T. Steck, D. F. Steiner, U. Storb, F. H. Straus II, L. P. Straus,
B. S. Strauss, P. Strieleman, S. Szuchet, W.-J. Tang, E. W. Taylor, G.
Thinakaran,
K. Thompson, A. Turkewitz, R. Tuttle, P. Ulinski, L. M. Van Valen, M. Verp, P. Vezina, M. Villereal, P. Wagner, C.-R. Wang, M. Westneat, W. Wimsatt, A. Wolfe, T.-W. Wong,
J. T. Wootton, C. Wu, R. Zaragoza,
X. Zhuang, Y. Zou
Courses: Biological Sciences (bios)
Students must confirm their registration with their instructors by the second class meeting or their registration may be canceled. In the following course descriptions, L indicates courses with a laboratory.
Biological Sciences Sequences for Nonmajors
Students choose from the following options to meet the biological sciences requirement. The requirement should be completed by the end of the second year. Students must confirm their registration with their instructors by the second class meeting or their registration may be canceled.
1. Students in this sequence take Biological Issues and Paradigms (BIOS 10110) as their first course. For their second quarter, students choose from a menu of topics courses (BIOS 10111-19999) that are comprehensive reviews of specialized topics in the biological sciences. Nonmajors are encouraged to enroll in additional biological sciences courses that cover topics of special interest to them.
BIOS 10110. Biological Issues and Paradigms. (=ENST 12202, NTSC 12202) This course addresses the question "what is life?" with a discussion of topics that range from the essential properties characteristic of all life to the complexities of evolution and interactions between all forms of life in the biosphere. Students in the course develop a broad common core of understanding of the nature of life through lectures, small group discussions, writing, and laboratory investigations. Laboratory fees apply. A second biology course (listed under "Topics Courses below") builds on this core knowledge, focusing on a specialized topic of biological inquiry. Autumn, Winter, Spring.
Multiple sections of this course are offered each quarter. Each section is taught from a different perspective by one of five faculty members based upon the specialty of the instructor. The Time Schedules will contain a "key descriptive word" in the notes for each section so students can register for the version that best suits their interests.
A. "From Molecules to Ecosystems" (key word: current) emphasizes how biological systems work, from macromolecules through cells and organisms to ecosystems. B. Fineschi. Autumn, Spring.
B. "Current Issues in Biology" (key word: comprehensive) comprehensively covers modern biology. Subjects explored include current issues in genomics (the Human Genome Project), proteomics (the proteins the genome codes for), and stem cell biology. T. Christianson. Autumn, Spring.
C. "Pharmacology Perspective" (key word: pharmacology) describes how drugs work at the cellular and organismal level, and covers advanced topics in cellular, molecular, and organismal biology. R. Zaragoza. Autumn, Spring.
D. "Infectious Disease" (key word: infections) covers major concepts in biology (molecular biology, genetics, evolution) by focusing on the molecular basis of human diseases and the prevention and treatment of diseases such as HIV and cancer. I. Pavlova. Autumn, Winter.
E. "Organisms to Ecosystems" (key word: org, ecol, & evol) emphasizes evolution, ecology, and physiology with the use of readings from the primary literature as well as popular scientific publications. A. Hunter. Winter.
F. "Quantitative Biology" (key word: quantitative) integrates mathematics with organismal, evolutionary, and ecological aspects of biology for science majors and students with prior knowledge of biology and basic mathematics skills. Students must perform well on the Biology Diagnostic Examination. A. Hunter, Autumn; E Larsen, Winter, Spring.
2. "Nature of Life" (BIOS 10400/10401) is an alternative sequence to BIOS 10110 and a topics course. It is appropriate for students who are interested in a more chemical and molecular introduction to biology and have a strong background in high school chemistry.
BIOS 10400. Molecular and Cellular Nature of Life. This course is the first in a sequence that is an alternative to BIOS 10110 for students interested in the more chemical and molecular aspects of biology. In this course we examine the principles underlying the universal processes on which all forms of life, from humans to dandelions to bacteria, are based. We begin by discussing the fundamental chemical strategies that mediate energy conversion, coupling of metabolic pathways, and information storage and expression. With that understanding, we discuss crucial characteristics of life phenomena at the cellular level and then conclude the course with a look at the rapidly advancing field of genetic engineering and its far-reaching implications for our lives. Winter. L.
BIOS 10401. The Origin of Life. PQ: BIOS 10400. This course is the second in a sequence that is an alternative to BIOS 10110 for students interested in the more chemical and molecular aspects of biology. In this course we discuss current thinking about the processes by which life emerged from just a few abiotic molecules and evolved into the present-day dazzling structural complexity characteristic of life. We begin by defining what is necessary and sufficient for life at its most basic level and discussing the fundamental chemical strategies that support life. With that understanding, we examine in some depth current theories and conjectures regarding chemical evolution and the emergence of the very first cell, the precursor to all life on the Earth. Spring.
Topics Courses for Nonmajors
The courses below have a prerequisite of BIOS 10100 or 10110, or a score of 4 or 5 on the AP biology test. Attendance is required at the first class to confirm enrollment.
11108. Human Heredity. PQ: BIOS 10100 or 10110. This course introduces the progress and problems in human genetics. Topics include genetic and physiologic determinants of sex, patterns of human inheritance, analysis of DNA and DNA fingerprinting, DNA cloning, prenatal genetic diagnosis, the genetics of complex traits, and the genetics of human populations. Assignments are based on current newspaper or magazine articles that reflect the interaction of genetics with some political, social, economic, or ethical issue. B. Strauss. Winter.
11109. Molecules to Cells and Back. PQ: BIOS 10100 or 10110. Selected topics of current medical and/or environmental interest are used to illustrate basic principles of cell and molecular biology. T. Martin. Spring.
11111. The Impact of Modern Genetics. PQ: PQ: BIOS 10100 or 10110. After presenting a history of genetics and modern molecular biology, the course presents the ways in which genomes of higher organisms can be analyzed and the implications of such analysis. Topics include genetic engineering of plants and animals, genetic screening, and relationship of genetics to disease and disease susceptibility. W. Epstein. Autumn.
11116. Genetic Engineering. PQ: BIOS 10100 or 10110. This course covers the history and technology of the efforts of humans to manipulate the genetic makeup of organisms. We focus most of our attention on genetic engineering in the production of agricultural, industrial, and medical products. We engage as a group in some virtual engineering projects. We also assess the ethical and public policy issues that are raised by rapid advances in genetic engineering technology. Field trips to sites where the work of genetic engineers is on display required. L. Mets. Spring.
11119. The Biology of Gender. PQ: BIOS 10100 or 10110. This course explores the biological evidence and theories that seek to explain gender in humans. The course relies on current research in neuroscience, physiology, and cell biology to address such topics as the genetics of gender; sexual differentiation of the fetus; sexually dimorphic brain regions; the biology of gender identity and gender preference; and hormonal/environmental contributions to gender. M. Osadjan. Autumn.
11122. Topics in Environmental Biology. (=ENST 12402, NTSC 12402) PQ: BIOS 10100 or 10110 or consent of instructor. This course qualifies as the second biological sciences course in the environmental sciences sequence. We consider human interaction with the natural environment at several levels of basic biology: molecular, cellular, genetic, and ecological. T. Steck, A. Turkewitz . Winter.
12106. Human Physiology. PQ: BIOS 10100 or 10110. This lecture/discussion class deals with topics of human physiology. The subject matter is divided into three main categories: relationship between form and function; biological order, regulation, and homeostasis; and unity within diversity and human perspective. S. Patel. Spring.
12107. Cell Biology of Physiological Stress. PQ: BIOS 10100 or 10110. This course studies the application of cell biology principles to physiological stress. We use paradigms such as fasting to talk about organ interactions (e.g., the Cori cycle). This includes discussions of receptors, kinases, and other cellular biology. M. Musch. Autumn.
12108. Biology and the Human Condition. PQ: BIOS 10100 or 10110. We discuss the insights that biology offers into some perennial human questions. Do the biological imperatives for reproduction and population growth inevitably conflict with the goals of a civilized society? Why do disease and suffering persist? In what ways are all people similar and in what ways is each individual unique? How do our genetic inheritances and our individual experiences interact in development? Is there a "human nature?" R. Perlman. Autumn.
12113. Human Physiology for Everyday Life. PQ: BIOS 10100 or 10110. This course is not intended for students interested in preparing for the health professions. Lecture topics cover all human body organ systems ranging from cardiovascular to reproductive in order to discuss the basic principles of human physiology. A special emphasis is placed on relating these physiologic principles to common diseases one encounters in everyday life. T. Baman. Autumn.
12114. Nutritional Science. PQ: BIOS 10100 or 10110. This course examines the underlying biological mechanisms of nutrient utilization in humans and the scientific basis for setting human nutritional requirements. The relationship between food choices and human health are also explored. Students consider how to assess the validity of scientific research that provides the basis for advice about how to eat healthfully. Class assignments are designed to help students apply their learning by critiquing nutritional health claims and/or current nutrition policy issues. P. Strieleman. Spring.
12115. From Eggs to People. PQ: BIOS 10100 or 10110. This course introduces developmental biology and, in the process of the answering questions such as the following, students learn about morphogenesis and pattern formation as well as consider how embryogenesis occurs in a number of vertebrate animal systems. How does the fertilized egg, which is a single cell, become a complicated organism? How do other creatures use similar arrays of cells and developmental strategies but manage to look very different from people? How does a cell know where it is in an embryo and yet also know what it should become? D. Kane. Winter.
13106. The Hungry Earth, Light, Energy, and Subsistence. PQ: BIOS 10100 or 10110. This class considers of the continuing erosion of the resources of the Earth by the persisting pressures of a growing human population, which makes a broad knowledge and appreciation of biology essential. Discussion includes the principles of energy conversion by plants as primary producers, the evolution of the structures and mechanisms involved in energy conversion, the origin of crop plants, improvements of plants by conventional breeding and genetic engineering, and the interactions of plants with pathogens and herbivores. M. Ruddat. Winter.
13107. Environmental Ecology. (=ENST 12404, NTSC 10400) PQ: BIOS 10100 or 10110. This course emphasizes basic scientific understanding of ecological and evolutionary principles that relate most closely to the ways humans interact with their environments. Topics include population growth, adaptation, and ecosystem structure and function. We also discuss the regulation and consequences of biodiversity. Discussion required. T. Price. Winter.
13109. Ecology. PQ: BIOS 10100 or 10110. Ecology is the study of the distribution and abundance of organisms. This course highlights key themes in ecology (e.g., how the environment affects species, evaluating the viability of populations, the implications for interactions among species, and the function of ecosystems). Emphasis is placed on how ecological information is being applied in the area of conservation biology. C. Pfister. Autumn, 2005.
13118. Genetically Modified Organisms. PQ: BIOS 10100 or 10110. In this course, we discuss issues surrounding the production of genetically modified organisms. We begin by understanding genetic manipulation and how it can enhance agriculture and medicine. We then focus on critically evaluating the scientific basis of health and environmental concerns. Readings from the primary literature are supplemented with background information on genetic technologies and with presentations from the media. The class includes lectures, videos, student presentations, and extensive discussions. J. Bergelson. Winter.
13120. Economic Plants and Human Health. PQ: BIOS 10100 or 10110. The profound influence of plants on the economic development of human societies is based on their wide usage for food, medicine, and numerous other applications. We focus on plants that provide essential nutrients, medicines, and luxurious commodities, and on how agriculture and trade of plant products determines issues of world hunger and economic development. As a group, we explore alternative means of managing agricultural and medicinal plants to address problems of world hunger and economics. Opportunities for field trips and hands-on experiences are also part of this course. I. Pavlova. Spring.
13323. Ecology to Agroecology: Human Impacts on Natural Environments. (=ENST 12403, NTSC 12403) PQ: BIOS 10100 or 10110 or consent of instructor. This course qualifies as a topical course for the biological sciences General Education requirement and as the second Biological Sciences course in the Environmental Sciences sequence. We examine how ecosystems function with and without human management. Topics include nutrient cycles in soil and plants, relationships among plants and animals, biodiversity and environmental conservation. Agroecosystems illustrate ecosystem complexity and human impact. N. Gift. Autumn.
13330. Introduction to Biological Anthropology. PQ: BIOS 10100 or 10110. This course provides a general evolutionary framework for the 360 living and 470 fossil primate species as a background to considering modern humans and their direct fossil relatives. Applications of chromosomal studies (karyology) and biomolecular comparisons (molecular phylogenetics) are also covered to establish the evolutionary framework. Other topics include principles of classification, principles of phylogenetic reconstruction, scaling effects of body size, primates in the context of mammal evolution, diets and dentitions, locomotor morphology and behavior, morphology and function of sense organs, evolutionary aspects of the brain, reproductive biology, and social organization. Each lecture concludes with a discussion of implications for human evolution. R. Martin. Spring 2005.
14107. Workings of the Human Brain. PQ: BIOS 10100 or 10110. This course is designed to give students an overview of the many functions of the brain, including perception, movement, language, emotion, memory, and sleep. We use a model of disease or dysfunction in an area of the brain to understand its normal functioning. This approach is complemented by presenting modern methods such as functional MRI and by reviewing historical milestones in neuroscience. Attendance required at each class meeting including lectures, labs, review sessions, and screenings of videotapes and imaging sessions. A. Noronha. Spring.
14108. Introduction to the Nervous System. PQ: BIOS 10100 or 10110. Extensive biology background not required but some knowledge of the field is helpful. This course is designed for students who are interested in learning the biology of the nervous system. Information is disseminated in the form of lectures that cover the basic principles and discussion sessions that illustrate specific examples. We cover compartments within the nervous system, development of different neuronal subtypes, neuronal connectivity, and neural activity in embryos and its role in sculpting neuronal connectivity. K. Sharma, Y. Zou. Autumn.
14109. Physiology of Addiction. PQ: BIOS 10100 or 10110. This course surveys the biological basis of substance abuse and substance addiction. We examine common addictions (e.g., caffeine, nicotine) to specialty drugs (e.g., ecstasy, anabolic steroids). Topics include: (1) an introduction to human metabolism and neurophysiology; (2) the mode of action of various substances on the nervous system; and (3) the storage, metabolism, and clearance of substances in the body. M. Osadjan. Winter.
14110. Neurobiology of Aging. PQ: BIOS 10100 or 10110. This course studies the neurobiological basis of healthy aging as well as the neurobiology of diseases that can occur in pathological aging (e.g., mild cognitive impairment, Alzheimer's disease, vascular dementia). We examine healthy aging through the pathological models of diseases prevalent in today's aging society and discuss modern methods used to diagnose these conditions. M. Carillo. Spring.
15106. Plagues: Past and Present. PQ: BIOS 10100 or 10110. This course explores selected examples of ancient, re-emerging, and emerging pathogens in the context of biology, as well as epidemiology and the selective pressures that influence the spread and control of epidemics. Emphasis is placed on the biological basis of how microbes gain access to and cause damage in their hosts and the struggle between the pathogen and the host's immune system. Students also gain an understanding of the basis for diagnostic procedures, treatments, and immunization. Discussion sessions required in addition to lectures. S. Boyle-Vavra. Winter.
15108. Immune System in Health and Disease. PQ: BIOS 10100 or 10110. This class introduces basic concepts of molecular biology and immunology. Subjects discussed include principles and applications of genetic engineering; defense mechanisms against infection and cancer; and various disorders of the immune system (e.g., allergy, autoimmunity, AIDS). C.-R. Wang. Winter, 2006.
15109. The Origins of Cancer. PQ: BIOS 10100 or 10110. In this lecture/discussion course, the molecular biology and clinical aspects of cancer are considered in tandem. In particular, the most prevalent malignant tumors (e.g., those arising in the breast, prostate, colon, and lung) are used as examples. T. W. Wong. Spring.
15111. Epithelium and Intestinal Flora. PQ: BIOS 10100 or 10110. This lecture/discussion course introduces students to the symbiotic relationship between humans and their intestinal flora on a cellular and molecular level. Special emphasis is given to understanding the benefits derived from normal gut flora as well as the molecular mechanisms responsible for diarrhea, inflammatory bowel disease, and cancer. Students discuss recent original experimental work in related fields. J. Sun, M. Hobert. Spring.
15112. Biological Poisons and Toxins. PQ: BIOS 10110 or 10100. This course explores biological poisons and toxins found throughout our environment. Toxins can originate from bacteria (i.e., anthrax, tetanus, botulinum, cholera), plants (i.e., ricin, curare, opiates), marine organisms (i.e., tetrodotoxin and saxitoxin), mushrooms (i.e., amanitin), frogs (i.e., batrachotoxin), and other organisms. We place emphasis on toxins that provide insight into the workings of the nervous system, cardiovascular system, and gastrointestinal system. We also address current topics, including the weaponization of toxins in biowarfare and bioterrorism and we explore examples of therapeutic (i.e., Botox) and commercial uses of toxins. J. Kyle. Spring.
15118. Why Microbes Know So Much Immunology. PQ: BIOS 10100 or 10110. This course discusses the interactions between microbes and their human and animal hosts from an evolutionary perspective. Particular emphasis is given to the plague, AIDS, anthrax, tuberculosis, and other major forms of pestilence. The ever-changing complex interactions between infectious agents and of innate and adaptive immunity are presented. J. Quintans. Winter.
Biological Sciences Sequences for Majors and
Students Preparing for the Health Professions
Five-Quarter Fundamentals Sequences
BIOS 20181 through 20185
This five-course sequence is an integrated introduction to the breadth of biology as a modern scientific discipline. It is designed for students who are preparing for a career in the biological sciences or medical professions. The material in this sequence is largely the same as that in the BIOS 20190s sequence. Topics include cell and molecular biology, genetics, developmental biology, organismal biology, and ecology and evolution. The final two quarters of this sequence must be completed by choosing two of the following three courses: BIOS 20184, 20185, or 20194. Students registering for this sequence must have completed or placed out of General or Honors Chemistry or be enrolled concurrently in General or Honors Chemistry. Students who completed the first three courses in this sequence prior to Autumn 2004 must complete two of the following courses: BIOS 20184 (Biodiversity), 20185 (Ecology and Evolution), or 20195 (Organismal Physiology [available Spring 2005 only]). Either BIOS 20183 (Physiology) or 20193 (Physiology), but not both, is also an option in fulfilling this requirement.
20181. Cell and Molecular Biology. This course is an introduction to molecular and cellular biology that emphasizes the unity of cellular processes amongst all living organisms. Topics are the structure, function, and synthesis of nucleic acids and protein; structure and function of cell organelles and extracellular matrices; energetics; cell cycle; cells in tissues and cell-signaling; altered cell functions in disease states; and some aspects of molecular evolution and the origin of cells. T. Martin, C. Schonbaum. Autumn. L.
20182. Genetics. PQ: BIOS 20181. The goal of this course is to integrate recent developments in molecular genetics and the human genome project into the structure of classical genetics. Topics include Mendelian inheritance, linkage, tetrad analysis, DNA polymorphisms, human genome, chromosome aberrations and their molecular analysis, bacterial and virus genetics, regulatory mechanisms, DNA cloning, mechanism of mutation and recombination, and transposable elements. L. Mets, B. Lahn, P. Strieleman. Winter. L.
20183. Physiology. PQ: BIOS 20181 and 20182. This course focuses on the physiological problems that animals (including humans) face in natural environments; solutions to these problems that the genome encodes; and the emergent physiological properties of the molecular, cellular, tissue, organ, and organismal levels of organization. Lectures and labs emphasize physiological reasoning, problem solving, and current research. M. Feder, M. Osadjan. Spring. L.
20184. Biological Diversity. PQ: BIOS 20183 or 20193, or consent of instructor. An overview of the diversity of living organisms, both prokaryotes and eukaryotes, is presented. We emphasize the major groups of organisms, their evolutionary histories and relationships, and the biological and evolutionary implications of the characteristic features of each group. We discuss how the biosphere transformed to its present state over the past four billion years. M. LaBarbera, E. Larsen, C. Andrews. Autumn. L.
20185. Ecology and Evolution. PQ: BIOS 20181-20182 or 20191-20192. This course surveys the major principles of ecology and evolutionary biology. Topics in evolutionary biology include the evidence for evolution, the history of life, the mechanisms of evolution (e.g., mutation, selection, genetic drift), adaptation, speciation, the origin of evolutionary novelties, the origin of life, and human evolution. Topics in ecology include demography and life histories, competition, predation, and the interspecific interactions that shape the structure of ecological communities. G. Dwyer, J. Coyne, C. Andrews. Winter. L.
BIOS 20191 through 20195
This integrated sequence examines the fundamental biological processes that are the basis of all life. Topics include cell and molecular biology, genetics, developmental biology, ecology and evolution, and organismal biology. The final two quarters of this sequence must be completed by choosing two of the following three courses: BIOS 20184, 20185, or 20194. Before registering for BIOS 20191, students must have completed or placed out of General or Honors Chemistry or they must have consent of instructor. Students who completed the first three courses in this sequence prior to Autumn 2004 must complete two of the following courses: BIOS 20184 (Biodiversity), 20185 (Ecology and Evolution), or 20195 (Organismal Physiology [available Spring 2005 only]). Either BIOS 20183 (Physiology) or 20193 (Physiology), but not both, is also an option in fulfilling this requirement.
20191. Cell and Molecular Biology. PQ: CHEM 11300 or 12300, or consent of instructor. The fundamental molecular processes of cells are examined using evidence from biochemical, physiologic, and microscopic analyses. Topics include the logical, spatial, and temporal organization and regulation of metabolism; the formation and function of proteins, RNA, and DNA; generation and function of cellular structures and compartments; regulation of gene expression; the organization and regulation of cell growth and division; and cell-environment and cell-cell interactions. L. Mets, B. Glick, C. Schonbaum. Autumn. L.
20192. Genetics. PQ: BIOS 20191. The goal of this course is to integrate recent developments in molecular genetics and the human genome project into the structure of classical genetics. Topics include Mendelian inheritance, linkage, tetrad analysis, DNA polymorphisms, human genome, chromosome aberrations and their molecular analysis, bacterial and virus genetics, regulatory mechanisms, DNA cloning, mechanisms of mutation and recombination, and transposable elements. J. Malamy, G. Webb, C. Schonbaum. Winter. L.
20193. Physiology. PQ: BIOS 20191 and 20192. This course is concerned with fundamental physiological functions and their relation to structure. In multicellular organisms the responsibilities for preservation of an appropriate cellular milieu, substrate intake and metabolite excretion, circulation of substrates and metabolites, locomotion, and integration of function are achieved by specializations of cells into organs. The biological principles of organ development, interaction, regulation, and coordination to mediate survival of the organism are examined using models from simple multicellular organisms to humans. P. Schumacker, D. McGehee, M. Osadjan. Spring. L.
20194. Developmental Biology. PQ: First three quarters of either BIOS 20180s or 20190s. This course covers both the classical experiments that contributed to our understanding of developmental biology and the recent explosion of information about development made possible by a combination of genetic and molecular approaches. Examples from both vertebrate and invertebrate systems are used to illustrate underlying principles of animal development. J. Crispino, U. Schmidt-Ott, C. Schonbaum. Spring. L.
20195. Organismal Physiology. PQ: BIOS 20181 and 20182, or 20191 and 20192, or consent of instructor. This course is concerned with fundamental physiological functions and their relation to structure. In multicellular organisms the responsibilities for preservation of an appropriate cellular milieu, substrate intake and metabolite excretion, circulation of substrates and metabolites, locomotion, and integration of function are achieved by specializations of cells into organs. The biological principles of organ development, interaction, regulation, and coordination to mediate survival of the organism are examined using models from simple multicellular organisms to humans. P. Schumacker, D. McGehee, M. Osadjan. (meets with 20193) Spring 2005 only. L.
Two-Quarter AP 5 Fundamentals Sequence
(for students with a score of 5 on
the AP biology test)
A score of 5 on the AP biology test allows students to register for the two-quarter sequence below. For biological sciences majors, this sequence meets requirements for the major. Upon completion of the two-quarter AP 5 sequence students will have two credits in the major and they will have met the general education requirement for the biological sciences. Students preparing for the health professions will have met the general education requirement and will have credit for two electives. All students must register for BIOS 20239 (Winter Quarter). Students register for a second course chosen from the following list: BIOS 20244, 20243, or 25410 (with consent of instructor).
20239. Molecular Biology I. PQ: A score of 5 on the AP biology test, and prior or concurrent registration in General or Honors Chemistry. This course introduces the concepts and fundamentals of molecular biology. Topics include DNA, RNA, and proteins; basic methods in molecular biology; DNA replication, recombination, and transposition; transcription in prokaryotes and eukaryotes; translation; regulation of gene expression; post-transcriptional events; and current topics. Attendance is also required at lab sessions that meet once a week. T. Pan, R. Zaragoza. Winter. L.
20243. From Neurons to Behavior: The Morphological and Physio-logical Basis of Movement. PQ: Consent of instructor. This course meets requirements for the biological sciences major. This course examines movement systems at multiple levels of design and function integrating neurobiology, muscle morphology and physiology, skeletal mechanics, and the interaction of organisms with the physical environment. These topics are examined through lectures, readings from the primary literature, and labs. Lectures provide basics on each subject examples of recently published work. Readings complement the lectures and cover current issues in the relevant fields. Labs involve exposure to methodological approaches and work on a class research project that combines data collected with several of these techniques with the ultimate goal of publication. M. Hale. Spring. L.
20244. The BIO 2010 University of Chicago Initiative: Biophysics and Chemical Biology. PQ: First-year standing and a score of 5 on the AP biology test. This interdisciplinary seminar course is designed to prepare students for research at the interface between physical and biological sciences. Papers are drawn from recently published work of colleagues at the University of Chicago, allowing students to meet and interact with authors and to explore examples of approaches drawn from the physical sciences and applied as powerful tools to understand biological systems. Working in groups, the students master and critically review each paper, both in class and in essays. A lab section introduces core laboratories that provide researchers access to key technologies. S. Kron. Spring. L.
20249. Genome Informatics: Genome Organization, Expression, and Transmission. PQ: BIOS 20239. This seminar course examines how genomes are organized for coding sequence expression and transmission to progeny cells. The class discusses a series of key papers in the following areas: bacterial responses to external stimuli and genome damage, control of eukaryotic cell differentiation, complex loci regulating developmental expression in animals, centromere structure and function, position effect variegation, chromatin domains, chromatin remodeling, RNAi, and chromatin formatting. J. Shapiro. Spring.
Advanced-Level Courses
There are three types of advanced courses. In courses listed under the heading General Courses, instructors present the general principles and recent developments for broad areas within the biological sciences. Such courses are usually offered on a regular basis, either annually or biennially. In courses listed under the heading Specialized Courses, the focus is on either a topic of particular interest to the instructor or on topics that are examined at a more advanced level than in General Courses. Such courses are offered less regularly, as warranted by student and faculty interest. Unless otherwise stated, most General Courses and Specialized Courses assume mastery of the material covered in the Fundamentals Sequences. Courses listed under the headings Specialized Courses and Independent Study and Research may not be counted toward the courses required for the major with the exception of BIOS 00298.
The following list provides information for students who are planning programs of study. Letters after course titles refer to the subject matter presented in the course: (C) Cell and Molecular, Genetics, or Developmental Biology; (CI) Computer Intensive; (E&E) Ecology and Evolution; (F) Fundamentals Sequence; (MIV) Microbiology, Immunology, or Virology; (N) Neuroscience; (S) Specialized; and (O) Organismal. L indicates courses with laboratory.
Autumn Quarter
20181. Cell and Molecular Biology. L. (F)
20184. Biological Diversity. L. (F)
20191. Cell and Molecular Biology. L. (F)
20200. Introduction to Biochemistry. L. (F)
21207. Cell Biology. (C)
21227. Advanced Developmental Biology. (C)
21306. Human Genetics and Evolution. (C)
21336. Cell Signaling. (C)
22233. Comparative Vertebrate Anatomy. L. (O)
22257. Darwinian Medicine. (O)
23248. Primate Behavior and Ecology. (E&E)
23256. Fundamentals of Molecular Evolution. (E&E)
23351. Ecological Applications to Conservation Biology. (E&E)
23403. Systematic Biology. L. (E&E)
24204. Cellular Neurobiology. L. (N)
24208. Vertebrate Neural Systems. (N)
24221. Computational Neuroscience I: Single Neuron Computation. L. (N)
25206. Fundamentals of Bacterial Physiology. (MIV)
25256. Immunobiology. (MIV)
26099. Quantitative Topics in Biology I: Ecology. (CI)
29283. Neurology and Kant's Theory of Knowledge. (S)
29306. Evolutionary Processes. (S)
29405. Mathematical and Statistical Methods for Neuroscience I. (N)
Winter Quarter
20182. Genetics. L. (F)
20185. Ecology and Evolution. L. (F)
20192. Genetics. L. (F)
20200. Introduction to Biochemistry. L. (F)
20239. Molecular Biology I (AP 5). L. (F)
21208. Fundamentals of Molecular Biology. (C)
21209. Molecular Biology. (C)
21216. Introductory Statistical Genetics. (C)
21229. Genome Informatics: How Cells Reorganize Genomes. (C)
21319. RRP: Ribosomes, RNA, and Protein. (C)
21326. Molecular Biophysics: Theory and Application. (C)
22226. Human Developmental Biology. (O)
22234. Chordate Biology. L. (O)
22242. Biological Fluid Mechanics. L. (O)
23240. The Diversity and Evolution of Plants. L. (E&E)
23246. The Diversity and Evolution of Plants. (E&E)
23249. Animal Behavior. (E&E)
23289. Marine Ecology. (E&E)
23406. Biogeography. (E&E)
24205. Systems Neuroscience. L. (N)
24211. Neuroethology. L. (N)
24217. Conquest of Pain. (N)
24222. Computational Neuroscience II: Vision. L. (N)
25108. Cancer Biology. (MIV)
25116. Endocrinology I: Systems and Physiology. (MIV)
25210. Laboratory in Bacterial Physiology. L. (MIV)
25257. Advanced Immunology. (MIV)
25407. Organ Transplantation. (MIV)
26100. Quantitative Topics in Biology II: Physiology and Biochemistry. L. (CI)
26400. Introduction to Bioinformatics. L. (CI)
29281. Introduction to Medical Ethics. (S)
29296. Biological and Cultural Evolution. (S)
29406. Mathematical and Statistical Methods for Neuroscience II. (N)
Spring Quarter
20183. Developmental Biology. L. (F)
20193. Developmental Biology. L. (F)
20195. Organismal Physiology. L. (F)
20200. Introduction to Biochemistry. L. (F)
20242. Physiology. (AP 5). L. (F)
20243. From Neurons to Behavior. (AP 5) L. (N)
20244. The BIO2010 U of C Initiative: Biophysics and Chemical Biology. (AP 5). L. (F)
20249. Genome Informatics: Genome Organization, Expression, and Transmission. (F)
21200. Human Molecular Genetics. L. (F)
21304. Photosynthesis. L. (C)
21316. Biochemistry. (C)
21318. Molecular Biophysics. (C)
21356. Vertebrate Development. (O)
21407. Image Processing In Biology. (C)
22235. Vertebrate Biology. (O)
22244. Introduction to Invertebrate Biology. L. (O)
22247. Principles of Pharmacology. (N)
22248. Physiology of Vision. (N)
23250. Research in Animal Behavior. L. (E&E)
23252. Field Ecology. L. (E&E)
23254. Mammalian Ecology. L. (E&E)
23255. Introductory Paleontology. L. (E&E)
23266. Evolutionary Adaptation. (E&E)
23299. Plant Development and Molecular Genetics. (E&E)
23401. Mutualisms and Symbiosis. L. (E&E)
23407. Plant-Atmosphere Interactions. (E&E)
24207. Developmental Neurobiology. (O)
24218. Molecular Neurobiology. (N)
24223. Computational Neuroscience III: Language. L. (N)
24214. Cognitive Neuroscience. L. (N)
25109. Topics in Reproductive Biology and Cancer. (MIV)
25117. Endocrinology II: Nutrition and Diseases. (MIV)
25216. Molecular Genetic Analysis of Bacterial Pathogenesis. (MIV)
25258. Immunopathology. (MIV)
25286. Viruses of Eukaryotes. (MIV)
25306. Microbes of Men and Beast. (MIV)
25307. Molecular Genetic Analysis of Bacteriophage. (MIV)
25410. The BIO 2010 U of C Initiative: Viruses as Probes of Cellular Function. (MIV)
26317. Molecular Mechanisms of Cell Signaling. (C)
26401. Evolutionary Genomics. L. (CI)
29283. Neurology and Kant's Theory of Knowledge. (S)
29288. Genetics in an Evolutionary Perspective. (S)
29291. The History of U.S. Public Health. (S)
29298. Current Issues in Medical Economics. (S)
29326. Introduction to Medical Physics and Medical Imaging. (S)
29407. Mathematical and Statistical Methods for Neuroscience III. (N)
General Courses
Most general and specialized courses that are at the 20000-level and above assume mastery of the material covered in the Fundamentals Sequences. Students who have not yet completed these sequences should consult with the individual instructor and the BSCD senior adviser before registering for the following courses.
20200. Introduction to Biochemistry. PQ: BIOS 20181-20182 or 20191-20192, and CHEM 22000-22100/23100. This course meets the biochemistry requirement for the biological sciences major. This course examines the chemical nature of cellular components, enzymes, and mechanisms of enzyme activity, energy interconversions, and biosynthetic reactions, including template-dependent processes and some aspects of control mechanisms. P. Strieleman, M. Makinen, Autumn, Spring; P. Strieleman, H. Friedmann, Winter; P. Strieleman, Summer. L.
20256. Developmental Genetics and Evolution. (=EVOL 33700, ORGB 33700) PQ: BIOS 20239. The purpose of this course is to provide a developmental genetic perspective on evolutionary questions that have emerged in various disciplines, including developmental biology, paleontology, and phylogenetic systematics. Topics range from the evolution of gene regulation to the origin of novelties such as eyes and wings. These subjects are introduced in lectures, but the focus is on presenting and discussing original research papers. U. Schmidt-Ott. Spring.
20257. Experimental Biophysical Chemistry. PQ: BIOS 20239. This introductory, laboratory-based course is directed toward studying binding interactions of macromolecules with metal ions, small molecule ligands, and other macromolecules. The strength of binding interactions of proteins and enzymes are measured using different physical methods to evaluate and compare quantitative limits of precision and accuracy in determining equilibrium binding constants. M. Makinen, M. Yousef. Spring.
20260. Chordate Evolutionary Biology. This course emphasizes the diversity and evolution of modern vertebrate life, drawing on a range of sources from comparative anatomy and embryology to paleontology, biomechanics, and developmental genetics. Much of the work is laboratory-based, with ample opportunity to gain first-hand experience of the repeated themes of vertebrate bodyplans as well as some of the extraordinary specializations manifest in living forms. N. Shubin, M. Coates. Spring.
21200. Human Molecular Genetics. PQ: Completion of BIOS 201801s or 20190s. This course considers the different types of variation in the human genome and the tools that are used to characterize human genetic variation at the individual and population levels. We further explore how this variability is utilized to (1) understand the molecular pathology of human disease, (2) aid in the diagnosis of human disease, (3) reconstruct human evolutionary origins and population history, and (4) unravel the evolutionary history of human genes and gene families. C. Ober, A. Di Rienzo. Winter. L.
21207. Cell Biology. PQ: BIOS 20200 or equivalent. This course surveys gene organization and expression; functions of the cell nucleus, cytoskeleton, and cytoplasmic structures; and cell-cell interactions and signaling. G. Lamppa, R. Haselkorn. Autumn.
21208. Fundamentals of Molecular Biology. (=BCMB 31000, GENE 31000, MGCB 31000) PQ: Basic knowledge of genetics and biochemistry. Third- or fourth-year standing. This course covers structure of genetic material, replication, recombination, transcription and its regulation, and post-transcriptional regulation, chromatin and DNA repair (both after transcription), and protein synthesis. U. Storb, J. Staley. Winter.
21209. Molecular Biology. PQ: BIOS 20200. This class focuses on current concepts in gene regulation at both the transcriptional and post-transcriptional levels. Topics include regulation of transcription initiation and elongation, pre-mRNA splicing and processing, RNA export, mRNA turnover, translational controls, protein degradation, and protein modification. Emphasis is placed on eukaryotic examples, but prokaryotic models are discussed where appropriate. H. Singh, S. Kron. Winter.
21216. Introductory Statistical Genetics. PQ: BIOS 21200, college-level statistics course, and consent of instructor. Our goal is that class members gain an understanding of genetic models for complex human disorders and quantitative traits. Students also learn how to conduct parametric and non-parametric linkage analyses, as well as linkage disequilibrium mapping using transmission/disequilibruim tests (TDT) and decay of haplotype sharing (DHS). N. Cox. Winter.
21227. Advanced Developmental Biology. (=DVBI 35400, MGCB 35400) PQ: BIOS 20182 or 20192. This course is an overview of the field of developmental biology, emphasizing the origins of classical concepts in the field as well as the modern molecular and genetic approaches to the study of developmental processes. Underlying mechanisms are illuminated through discussion of key experiments. Examples are drawn from the literature on invertebrate and vertebrate embryology. Subjects include induction, embryonic pattern formation, cell and tissue interactions, and the control of gene expression in development. E. Ferguson, D. Preuss. Autumn.
21229. Genome Informatics: How Cells Reorganize Genomes. PQ: BIOS 20182 or 20192. This course deals with the molecular and cellular basis of genetic change. We discuss DNA repair functions, mutator loci, induced mutation, mechanisms of homologous recombination and gene conversion, site-specific recombination, transposable elements and DNA rearrangements, reverse transcription and retrotransposons, transposable vector systems for making transgenic organisms, and genetic engineering of DNA sequences in antibody formation. Discussion section required. J. Shapiro. Winter.
21304. Photosynthesis. PQ: BIOS 20200 and 20180s, or 20190s. Fundamental photosynthetic processes occur on time domains of femtoseconds, minutes, seasons, centuries, and eons. Critical photosynthetic events occur on molecular, sub-cellular, cellular, organismal, ecosystem, and global scales. This course considers photosynthesis as an integrated whole over both its temporal and spatial domains. Chemical, biophysical, biochemical, genetic, developmental, physiologic, ecological, and evolutionary methods are employed to analyze the net processes and detailed mechanisms of photosynthesis. L. Mets. Spring, 2005. L.
21306. Human Genetics and Evolution. PQ: BIOS 20180s or 20190s, or consent of instructor. Open only to students with advanced standing who are majoring in the biological sciences or preparing for the medical professions. This course deals with issues in genetics of variations within, as well as between, modern human populations. Normal genetic variations and the genetic basis of human diseases are explored with an emphasis at the molecular level. The course stresses understanding the fundamental concepts of genetics and evolution using mainly, but not exclusively, human studies as examples. Genome organization, genetic mapping, population genetic theories, and molecular evolution of humans are covered. C.-I. Wu, R. Hudson. Autumn.
21316. Biochemistry. PQ: BIOS 20200. Required of biological chemistry majors. This course examines a variety of biological problems from a chemical and structural perspective. Topics include macromolecular structure-function relationships, DNA and protein synthesis and repair, RNA folding and catalysis, molecular motors, nitrogen fixation; photosynthesis; and mechanisms of signal transduction. Computer graphics exercises complement the lecture topics. W. Hoff, P. Rice. Spring.
21318. Molecular Biophysics. (=BCMB 32400) PQ: CHEM 22000-22100/23100 and college-level physics, or consent of instructor. This is an introductory course emphasizing concepts of physical chemistry important in the interactions of biological macromolecules, with emphasis on structure, dynamics, and kinetics. The course focuses on basic aspects of secondary and tertiary structure, the origin and basis of electrostatic and hydrophobic interactions, dynamical properties of proteins, and the structural basis of enzyme action. Problem sets, including use of molecular graphics workstations, are coordinated with lectures. M. W. Makinen, W. Hoff. Spring.
21319. RRP: Ribosomes, RNA, and Protein. PQ: General Chemistry, Organic Chemistry, and BIOS 20200. This course is devoted to RNA biochemistry and molecular biology and to RNA-protein interactions with special emphasis on ribosome structure and protein biosynthesis. Topics include the biochemistry of protein synthesis (i.e., the translation reactions such as initiation, elongation, and termination); tRNA structure and identity elements; rRNA (i.e., structure, processing, regulation of synthesis, function, and evolution); ribosomal proteins (i.e., structure, function, gene organization, regulation of synthesis); ribosome assembly; ribosome structure from immuno-electron microscopy, neutron scattering, and X-ray defraction; RNA (i.e., protein interactions including tRNA-aminoacyl-tRNA syntase, rRNA-ribosomal proteins, and other examples); and, finally, regulation and translation. I. Wool. Spring.
21326. Molecular Biophysics: Theory and Application. (=BCMB 32200) PQ: General chemistry, organic chemistry, and BIOS 20200. Third- or fourth-year standing, or consent of instructor. The course exposes students to modern biophysical methods and provide background for use of existing facilities at The University of Chicago. Topics include the measurement of physical properties of biological molecules such as structure, thermodynamics, and kinetics. We focus on practical aspects but also cover a sufficient amount of theoretical background to develop the proper understanding of the technique. T. Sosnick. Spring.
21336. Cell Signaling. (=CPHY 33600, NPHP 33600) PQ: BIOS 20200. The subject matter of this course considers the wide variety of intracellular mechanisms that, when activated, change cell behavior. Both general and specific aspects of intracellular signaling are covered in the course, the latter including detailed discussions of receptors, G-proteins, cyclic nucleotides, calcium and calcium-binding proteins, phosphoinositides, protein kinases, and phosphatases. C. Palfrey. Autumn.
21356. Vertebrate Development. (=DVBI 35600) PQ: BIOS 20180s or 20190s, and consent of course co-coordinator. This advanced-level course combines lectures, student presentations, and discussion sessions. It covers major topics on the developmental biology of embryos (e.g., formation of the germ line, gastrulation, segmentation, nervous system development, limb patterning, organogenesis). We make extensive use of the primary literature and emphasize experimental approaches (e.g., classical embryology, genetics, molecular genetics). K. Millen, V. Prince. Spring.
21407. Image Processing in Biology. (=MGCB 34300) PQ: One year of calculus. Whether one is trying to read radio signals from far-away galaxies or to understand molecular structures, it is necessary to understand how to read, interpret, and process the data that contain the desired information. In this course we learn how to process the information contained in images of molecules as seen in the electron microscope. This course deals with the principles involved in processing electron microscope images, including the underlying analytical methods and their computer implementation. R. Josephs. Spring.
22226. Human Developmental Biology. PQ: Completion of the general education requirement for the biological sciences. Prior chemistry and organismal biology courses. This course examines the physiologic, cellular, and biochemical functions of a series of organs and systems in their transition from fetal to newborn life in the human, and the implications of these changes for successful adaptation to independent life. Examples of failures of adaptation and disease states are presented and discussed. The organs and systems covered are brain, lung, heart, liver, immune system, blood-forming system, intestine, endocrine organs, and kidney. M. Schreiber. Winter.
22233. Comparative Vertebrate Anatomy. PQ: Fundamentals or AP 5 sequence. This course covers the structure and function of major organ systems of vertebrates, focusing on mammals, with lab dissection of animals and lectures covering a range of topics on the diversity, structure and function of animals including humans. M. Westneat. Autumn. L.
22234. Chordate Biology. PQ: Completion of the general education requirement for the biological sciences. This is a general consideration of the structure, evolution, phylogeny, and life history of vertebrates. We emphasize comparative morphology, as well as structural and functional evolution. N. Shubin, M. Coates. Winter. L.
22235. Vertebrate Biology. (=EVOL 30300, ORGB 31300) PQ: Completion of the general education requirement for the biological sciences. This new course covers the full spectrum of group diversity from jawless fishes to mammals, giving students an opportunity to learn about structure and function in lecture and lab based settings. A paleontological perspective, informed heavily by the instructors' own research programs, is included to familiarize students with patterns and directions of change through "deep time," to introduce different kinds of data, and to show how these disparate sources integrate in modern bioscience. N. Shubin, M. Coates. Spring. L.
22242. Biological Fluid Mechanics. PQ: Completion of the general education requirement for the biological sciences. Prior physics course required; prior chemistry and calculus courses recommended. This course is an introduction to fluid mechanics and the interactions between biology and the physics of fluid flow (both air and water). Topics range from the fluid mechanics of blood flow to the physics (and biology) of flight in birds and insects. M. LaBarbera. Winter, 2007. L.
22243. Biomechanics of Organisms. PQ: Completion of the general education requirement for the biological sciences. Prior chemistry, physics, and calculus courses recommended. This course examines how organisms cope with their physical environment, covering the properties of biological materials, mechanical analysis of morphology, and principles of design optimization. We emphasize support systems of organisms but also examine aspects of cardiovascular design. Mechanical properties of biomaterials are analyzed in relation to their underlying biochemical organization and biophysical properties, with mathematical treatment at an introductory level. The lab research project is optional. M. LaBarbera. Winter, 2005. L.
22244. Introduction to Invertebrate Biology. PQ: Completion of the general education requirement for the biological sciences or consent of instructor. This is a survey of the diversity, structure, and evolution of the invertebrate phyla, with emphasis on the major living and fossil invertebrate groups. Structure-function relationships and the influence of body plans on the evolutionary history of the invertebrate phyla are stressed. M. LaBarbera. Spring, 2006. L.
22247. Principles of Pharmacology. PQ: BIOS 20200. This course considers the physiological and biochemical bases of drug actions, common pharmacological methods, and a small set of specific drugs and their targets. D. Hanck. Spring.
22248. Physiology of Vision. (=PSYC 25000/35000). PQ: Prior physics and calculus, and one of the following: BIOS 24236 or 24204, or PSYC 28000. This advanced course on primate visual physiology covers in detail cortical systems for object recognition, visual motion perception, depth perception, and heading (self-motion) perception. We also discuss basic components of visual computation, including frequency analysis, computational mapping, gain normalization, and population coding. D. Bradley. Spring.
22257. Darwinian Medicine. (=HIPS 25900) PQ: Completion of the general education requirement for the biological sciences. This course discusses human health and disease in an evolutionary perspective and emphasizes how principles from evolutionary biology, ecology, and genetics can increase our understanding of the physiological mechanisms and populational processes that affect the maintenance of health and origin of disease. Topics include host-parasite interactions; the evolution of virulence and of host defenses; the ecology of emerging diseases, including AIDS; the cultural and social contexts of disease; and epigenetic mechanisms in health and disease. R. Perlman, W. Wimsatt. Autumn.
22260. Vertebrate Structure and Function. PQ: BIOS 22233 or consent of instructor. This course is devoted to vertebrate bones and muscles, and we discuss some of the remarkable functions they perform. The first part of the course takes a close comparative look at the vertebrate skeleton via development and evolution, from lamprey to human. The major functional changes will be examined, as vertebrates adapted to life in the water, land, and air. The second part of the course takes at close look at muscles and how they work in specific situations, including gape-feeding, swimming, leaping, digging, flying, and walking on two legs. Dissection of preserved vertebrate specimens is required. P. Sereno. Spring. L.
23100. Dinosaur Science. PQ: Prior course in general science, preferably geology or biology. Consent of instructor. This class introduces basic geology (e.g., rocks and minerals, stratigraphy, earth history, and mapping skills) and basic evolutionary biology (e.g., vertebrate and skeletal anatomy, systematics, large-scale evolutionary patterns). Students fly from Chicago to Rapid City and then travel by van to actual paleontological sites in South Dakota and Wyoming to prospect for and excavate fossils from the Cretaceous and Jurassic Periods. Participation in a field trip from June 12 to 26 is required; students work under challenging field conditions that involve camping, hiking over rugged terrain, and excavating during typical summer conditions. P. Sereno. Spring. L.
23240. The Diversity and Evolution of Plants. PQ: Completion of the general education requirement for the biological sciences. The lectures address the diversity in morphology, anatomy, reproduction, and evolutionary trends, beginning with cyanobacteria and progressing to flowering plants. The unifying aspects of cell structure and function are emphasized, along with the basic physiological and molecular mechanisms in plants. The lab is correlated with the lectures to examine representatives of the major taxonomic plant groups and basic physiological techniques. This course is identical to BIOS 23246 except that it has a lab. M. Ruddat. Winter. L.
23241. Primate Evolution. This course is the first of three in the Primate Biology and Human Evolution sequence (see also BIOS 23248 and BIOS 23253). The course provides a general introduction to the evolution of nonhuman primates and humans, with emphasis on taxonomic classification, the use of fossil and genetic evidence for phylogenetic reconstructions, the evolution of primate morphological and physiological characteristics (e.g., body and brain size, skull and skeleton, sense organs, and dietary and reproductive adaptations), the adaptive radiation of Prosimians, New World Monkeys, Old World Monkeys, and apes into their current areas of geographic distribution, and an overview of the hominid fossil record. R. Martin. Autumn.
23246. The Diversity and Evolution of Plants. PQ: Completion of the general education requirement for the biological sciences. This course is identical to BIOS 23240 except that it does not have a lab. M. Ruddat. Winter.
23248. Primate Behavior and Ecology. (=EVOL 37300, HUDV 21800) PQ: Completion of the general education requirement for the biological sciences. This course is the second of three in the Primate Biology and Human Evolution sequence (see also BIOS 23241 and BIOS 23253). For course description, see Human Development. D. Maestripieri. Winter.
23249. Animal Behavior. (=HUDV 23249, PSYC 23249) PQ: Completion of the general education requirement for the biological sciences. This course provides an introduction to the mechanism, ecology, and evolution of behavior, primarily in nonhuman species, at the individual and group level. Topics include the genetic basis of behavior, developmental pathways, communication, physiology and behavior, foraging behavior, kin selection, mating systems and sexual selection, and the ecological and social context of behavior. A major emphasis is placed on understanding and evaluating scientific studies and their field and lab techniques. S. Pruett-Jones, J. Mateo. Winter.
23250. Research in Animal Behavior. (=EVOL 33200) PQ: BIOS 23249 or consent of instructor. Students develop and collect data on an independent research project of their choosing. Training in the methods of behavioral research precedes the initiation of the research projects. Discussion with the instructor and TA facilitates progress. Students analyze and interpret data, and present their findings orally or in poster form, as well as in written form, at the end of class. All behavioral observations are conducted at Brookfield Zoo. S. Margulis. Spring, 2006.
23252. Field Ecology. PQ: Consent of instructor. Open only to students planning to pursue graduate research. This course is an introduction to habitats and biomes in North America and the methods of organizing and carrying out field research projects in ecology and behavior, focusing on questions of evolutionary significance. The course consists of a two-week field trip to southern Florida during the Winter/Spring Quarter break. The field trip consists of informal lectures and discussions, individual study, and group research projects. During Spring Quarter there are lectures on the ecology of the areas visited and on techniques and methods of field research. S. Pruett-Jones. Spring. L.
23253. Apes and Human Evolution. (=ANTH 28600/38600, EVOL 38600, HIPS 23700) BIOS 23241 recommended. For course description, see Anthropology. Visits to local zoos, films, and demonstrations with casts of fossils and skeletons required. R. Tuttle. Spring, 2005. L.
23254. Mammalian Ecology. PQ: Completion of the general education requirement for the biological sciences and third year standing; or BIOS 20184 or 20185. This course is an introduction to the diversity and classification of mammals and their ecological relationships. Lectures cover natural history, evolution, and functional morphology of major taxonomic groups. Lab sessions focus on skeletal morphology, identifying traits of major taxonomic groups, and methods of conducting research in the field. Participation in field trips, occasionally on Saturday, is required. E. Larsen. Spring. L.
23255. Introductory Paleontology. (=EVOL 32300, GEOS 22300) PQ: GEOS 13100-13200, or PHSC 10900/11000, or completion of the general education requirement for the biological sciences, or consent of instructor. For course description, see Geophysical Sciences. M. Foote. Spring. L.
23256. Fundamentals of Molecular Evolution. PQ: Prior calculus course or consent of instructor. This course covers evolutionary forces governing molecular variation and divergence and genome organization. It explores the evolutionary assembly of genes, the origin of novel gene function, the population genetics of repetitive DNA variation, and the evolution of multigene families. The course also provides practical information on accessing genome databases, searching for homologous sequences, aligning DNA and protein sequences, calculating sequence divergence, producing sequence phylogenies, and estimating evolutionary parameters. M. Kreitman, T. Nagylaki. Autumn.
23266. Evolutionary Adaptation. PQ: BIOS 20185 or 20239; and BIOS 20240. This course deals with the adaptation of organisms to their environments and focuses on methods for studying adaptation. Topics include definitions and examples of adaptation, the notion of optimization, adaptive radiations, and the comparative method in evolutionary biology. C. Andrews. Spring.
23289. Marine Ecology. (=ENST 23289) PQ: Prior introductory course in ecology or consent of instructor. This course provides an introduction into the physical, chemical, and biological forces controlling the function of marine ecosystems and how marine communities are organized. The structures of various types of marine ecosystems are described and contrasted, and the lectures highlight aspects of marine ecology relevant to applied issues such as conservation and harvesting. T. Wootton. Winter.
23299. Plant Development and Molecular Genetics. (=DVBI 36100, ECEV 32900, MGCB 36100) PQ: Completion of the general education requirement for the biological sciences. This course describes the growth, differentiation, and development of plants at the organismal, cellular, and molecular levels. Emphasis is placed on the regulatory function of plant hormones, particularly in response to environmental stimuli and in control of gene expression. Recent advances using molecular genetic approaches in Arabidopsis and maize are a central feature of the course. M. Ruddat, J. Greenberg. Spring.
23351. Ecological Applications to Conservation Biology. (=ENST 25100) PQ: Completion of the general education requirement for the biological sciences. We focus on the contribution of ecological theory to the understanding of current issues in conservation biology. The course emphasizes quantitative methods and their use for applied problems in ecology, such as the design of natural reserves, the risk of extinction, the impact of harvesting, the dynamics of species invasions, and the role of species interactions. Course material is drawn mostly from the current primary literature. J. Bergelson, C. Pfister. Autumn, 2004. L.
23401. Mutualisms and Symbiosis. PQ: Completion of the general education requirement for the biological sciences or consent of instructor. Fungi, bacteria, and other microbes are often intimately associated with plants and animals in diverse mutualistic and other symbiotic relationships. This course focuses on the importance and intricacies of these associations. A survey of the variety of mutualisms with animals and plants is presented. Plant/fungus mutualisms highlighted include mycorrhizae, endophytes, and lichens. Morphological, physiological, and ecological aspects of these associations are treated. G. Mueller. Spring, 2005. L.
23403. Systematic Biology. (=EVOL 35400) PQ: Completion of the general education requirement for the biological sciences. This course carefully explores the concepts of homology, relationships, species, and higher taxa. We also cover modern methods of phylogeny reconstruction including morphological and molecular approaches. We consider the central role of systematic biology in the biological sciences and its connection to the fossil record, ontogeny, biogeography, taxonomy, and conservation. M. Kearney. Autumn. L.
23406. Biogeography. (=ENST 25500, EVOL 45500, GEOG 25500/35500) PQ: Completion of the general education requirement for the biological sciences or consent of instructor. This course examines factors governing the distribution and abundance of animals and plants. Topics include patterns and processes in historical biogeography, island biogeography, geographical ecology, areography, and conservation biology, such as the design and effectiveness of nature reserves. B. Patterson (odd years, lab); L. Heaney (even years, discussion). Winter.
23407. Plant-Atmosphere Interactions. PQ: Completion of a Fun-damentals Sequence (BIOS 20180s or 20190s). This course explores examples of plant-atmosphere and plant-climate interactions in the geological past, in the more recent past of Quaternary glacial-interglacial cycles, and from experimental studies of the present day. We provide a framework for understanding the nature and scale of evolution, adaptation, and ecophysiological responses of plants to their atmospheric and climatic environment. J. McElwain. Spring, 2005.
23408. Modeling and Computer Simulation of Evolution. (=HGEN 47200) PQ: Basic computer programming skills or willingness to learn some programming recommended. The goal of this class is to create theoretical models to describe and predict biological processes. Students learn how to implement these models on a computer and how to explore the properties of the models by computer simulation. We may consider examples in evolutionary biology that describe the evolution of organisms within and between species and models from ecology or infectious disease epidemiology. R. Hudson, J. Pritchard. Spring.
24204. Cellular Neurobiology. (=PSYC 31100) PQ: Completion of the general education requirement for the biological sciences. This course meets one of the requirements of the neuroscience specialization. This course is identical to BIOS 24236 except that it has a lab, which focuses on electrophysiological techniques used in analysis of issues fundamental to neural processing at the cellular level. These include monitoring membrane potential, carrying out voltage clamp of native and cloned ion channels, and investigating the control of synaptic transmission. D. Hanck, P. Lloyd. Autumn. L.
24205. Systems Neuroscience. (=PSYC 24000/31200) PQ: BIOS 24204 or 24236, or consent of instructor. This course meets one of the requirements of the neuroscience specialization. Students are introduced to vertebrate and invertebrate systems neuroscience with a focus on the anatomy, physiology, and development of sensory and motor control systems. The neural bases of form and motion perception, locomotion, memory and other forms of neural plasticity are examined in detail. We also discuss clinical aspects of neurological disorders. Labs are devoted to mammalian neuroanatomy and electrophysiological recordings from neural circuits in model systems. J. Ramirez, J. Goldberg, R. McCrea, M. Osadjan. Winter. L.
24207. Developmental Neurobiology. PQ: BIOS 24204 and 24205, and consent of instructor. This course examines the development of the vertebrate nervous system. We trace the development of the brain from the first induction of neural tissue in the embryo to the refinement of synaptic connections late in development by emerging brain activity. We discuss the new synthesis of classical experimental embryology and modern techniques of molecular biology that have led to several recent breakthroughs in our understanding of neural development. E. Grove, Y. Zou, N. Issa. Winter.
24208. Vertebrate Neural Systems. (=NURB 31600) PQ: Consent of instructor. This lab-centered course teaches students the fundamental principles of vertebrate nervous system organization. Students learn the major structures and the basic circuitry of the brain, spinal cord and peripheral nervous system. Somatic, visual, auditory, vestibular and olfactory sensory systems are presented in particular depth. A highlight of this course is that students become practiced at recognizing the nuclear organization and cellular architecture of many regions of brain in rodents, cats and primates. C. Ragsdale, P. Mason, N. Issa. Autumn. L.
24211. Neuroethology. (=PSYC 31500) PQ: BIOS 24204 or consent of instructor. Prior or concurrent registration in PHYS 14200. Prior knowledge of basic cellular mechanisms of neurons and basic anatomy of the vertebrate central nervous system. The design of this course considers the needs of advanced students who plan to pursue graduate work, particularly in neurobiology or experimental psychology. It covers topics in systems, computational, and behavioral neuroscience. There is a heavy emphasis on original literature, and oral and written scientific presentations. Labs include exposure to instrumentation and electronics, and involve work with live animals. Labs meet once a week and may require time beyond the posted schedule. D. Margoliash. Winter. L.
24214. Cognitive Neuroscience. (=CPNS 30200, PSYC 34214) PQ: One year of college-level calculus and prior course in systems neuroscience. This course meets one of the requirements of the neuroscience specialization. This course is concerned with the relationship of the nervous system to higher order behaviors such as perception, action, attention and learning and memory. Modern methods of imaging neural activity are introduced. Mathematical and statistical methods including dynamical systems theory, information theory, and pattern recognition for studying neural encoding in individual neurons and populations of neurons are discussed. N. Hatsopoulos. Spring. L.
24217. Conquest of Pain. PQ: CHEM 22000-22100-22200 or BIOS 20200 required; prior course in neurobiology or physiology recommended. This course examines the biology of pain and the mechanisms by which anesthetics alter the perception of pain. The approach is to examine the anatomy of pain pathways both centrally and peripherally, and to define electrophysiological, biophysical, and biochemical explanations underlying the action of general and local anesthetics. We discuss the role of opiates and enkephalins. Central theories of anesthesia, including the relevance of sleep proteins, are also examined. J. Moss. Winter, 2006.
24218. Molecular Neurobiology. PQ: BIOS 20200 and 24236 or 24204, or consent of instructor. This is a lecture/seminar course that explores the application of modern cellular and molecular techniques to clarify basic questions in neurobiology. Topics include mechanisms of synaptic transmission, protein trafficking, exo- and endo-cytosis, and development and mechanisms of neurological diseases. S. Sisodia. Spring.
24221. Computational Neuroscience I: Single Neuron Computation. PQ: Prior college-level course in calculus required; some background in neurobiology and concurrent registration in BIOS 2945 recommended. This course briefly reviews the historical development of computational neuroscience and discusses the functional properties of individual neurons. The electrotonic structure of neurons, functional properties of synapses, and voltage-gated ion channels are discussed. P. Ulinski, D. Hanck. Autumn. L.
24222. Computational Neuroscience II: Vision. PQ: BIOS 24221. Concurrent registration in BIOS 29406 recommended. This course considers computational approaches to vision. It discusses the basic anatomy and physiology of the retina and central visual pathways emphasizing computational approaches to vision based on control theory, linear and nonlinear systems theory and information theory. P. Ulinski, Staff. Winter. L.
24223. Computational Neuroscience III: Language. (=PSYC 34400) PQ: Consent of instructor. This course discusses computational approaches to human language. It examines the learning, production, and comprehension of language, through neural network modeling of human linguistic behavior, and through brain imaging. T. Regier, Staff. Spring, 2006. L.
25108. Cancer Biology. PQ: Completion of the general education requirement for the biological sciences. This course covers the fundamentals of cancer biology but focuses on the story of how scientists identified the genes that cause cancer. Emphasis is on "doing" science rather than "done" science: how do scientists think, how do they design experiments, where do these ideas come from, what can go wrong, and what it is like when things go right. M. Rosner. Winter.
25109. Topics in Reproduction and Cancer. PQ: BIOS 20180s or 20190s, or consent of instructor. This course focuses on several aspects of the molecular and cellular biology of human reproduction as well as the basis of chemical/viral carcinogenesis and the progression, treatment, and prevention of cancer. The role of steroid hormones and their receptors in the control of growth, development, and specialized cell function is discussed in the context of normal and abnormal gene expression in human development and disease. Key historical events, research approaches, utilization of knowledge, recent advances in drug design and herbal medicines, and philosophies of scientific research are also covered. G. Greene, S. Liao, R. Hippakka, J. Kokontis. Spring.
25116. Endocrinology I: Systems and Physiology. PQ: Completion of a Fundamentals Sequence (BIOS 20180s or 20190s or AP 5 sequence). Endocrinology is the study of chemical messengers, hormones, released by tissues that regulate the activity of other cells in the body. This course covers the classical hormone systems, including hormones regulating metabolism, energy mobilization and storage, calcium and phosphate metabolism, reproduction, growth, "fight or flight," and circadian rhythms. We focus on historical perspective, the mechanisms of action, homeostatic regulation, and relevant human diseases for each system. A. Wolfe, M. Brady. Winter.
25117. Endocrinology II: Nutrition and Diseases. Completion of a Fundamentals Sequence (BIOS 20180s or 20190s or AP 5 sequence) and BIOS 25116 recommended. This course offers a modern overview of the patho-physiologic, genetic, and molecular basis of human diseases with nutritional perspectives. Topics include human diseases such as hypertension, cardiovascular diseases, obesity, diabetes, osteoporosis, and alopecia. Y. C. Li, M. Musch. Spring.
25206. Fundamentals of Bacterial Physiology. (=MICR 30600) This course meets one of the requirements of the microbiology specialization. This course introduces students to bacterial diversity, physiology, ultra-structure, envelope assembly, metabolism, and genetics. In the discussion section, students discuss recent original experimental work in the field of bacterial physiology. D. Missiakas. Autumn.
25210. Experimental Physiology of Bacteria. (=MICR 31000) This course meets one of the requirements of the microbiology specialization. This course teaches students experimental techniques in bacteriology and molecular genetic analysis of bacteria and phage. Students work at the lab bench under supervision of the instructor and assistants to learn experimental techniques and fundamentals of bacterial physiology. T. Christianson. Winter. L.
25216. Molecular Genetic Analysis of Bacterial Pathogenesis. (=MICR 31600) This course meets one of the requirements of the microbiology specialization. This lecture/discussion course involves a comprehensive analysis of bacterial pathogens, the diseases that they cause, and the molecular mechanisms involved during pathogenesis. Students discuss recent original experimental work in the field of bacterial pathogenesis. D. Missiakas, Staff. Spring.
25256. Immunobiology. PQ: BIOS 20180s or 20190s, and consent of instructor. This course presents an integrated coverage of the tactics and logistics of immune phenomena and conveys the elegance of the biological solutions evolved by multicellular organisms in their fights against infectious agents. Immune phenomena are presented as unique evolutionary adaptations of vertebrates operating in the context of ancillary defense mechanisms. The various types of countermeasures evolved by pathogens are also discussed, with particular emphasis on HIV and discussions on AIDS. J. Quintans. Autumn.
25257. Advanced Immunology. PQ: BIOS 25256. This is a seminar-based course that examines current questions in immunology. Primary research papers describing landmark discoveries are discussed thoroughly with a special accent on experimental data and concepts. There are typically five selected topics (e.g., lymphocyte development, immunological memory, immune tolerance, innate immunity, lymphocyte homeostasis, T cell fate decisions). Emphasis is placed on a critical understanding of the literature and the development of hypotheses to explain current issues in immunology. P. Ashton-Rickardt, B. Jabri. Winter.
25258. Immunopathology. (=IMMU 30010, PATH 30010) PQ: BIOS 25257. This course explores the immunological basis of diseases. Five examples of diseases are selected each year among the following categories: autoimmune diseases, inflammatory bowel diseases, infection immunity, immunodeficiencies and gene therapy, and transplantation and tumor immunology. Each disease is studied in depth with general lectures including, where applicable, histological analysis of diseased tissue samples and discussions of primary research papers on experimental disease models. Special emphasis is placed on understanding immunopathology within the framework of general immunological concepts and on experimental approaches to the study of immunopathological models. B. Jabri, P. Ashton-Rickardt. Spring.
25259. Fundamental Issues in Immunology. PQ: BIOS 25258. This course is based on the study of fundamental areas of immunology, using exclusively the primary literature. Topics, which rotate yearly over a five-year cycle, may include immunological tolerance, immunological memory, regulation of the class of immune responses, innate and adaptive immune recognition, and lymphocyte development (hemopoiesis excluded). The aim of the course is to grasp the conceptual and technological milestones in a historical perspective, from some old classics up to recently published work. We emphasize the detailed analysis and discussion of experimental data and concepts. A. Bendelac. Autumn.
25286. Viruses of Eukaryotes. (=GENE 34600, MGCB 34600, VIRO 34600) PQ: Consent of instructor. This course meets one of the requirements of the microbiology specialization. This course is concerned with various aspects of the molecular biology of viruses of animal cells, including viruses that afflict man. Special emphasis is given to recent developments in the field related to viral nucleic acid replication, controls of viral gene expression, use of viruses as cloning vectors to amplify specific cellular genes, and the contribution of virus research to our understanding of mechanisms underlying eukaryotic gene expression. B. Roizman. Spring.
25306. Introduction to Microbes of Men and Beast. PQ: First three quarters of BIOS 20180s or 20190s, and 25256. This course is intended to teach the fundamentals underlying the pathogenesis of disease caused by various types of microbes (e.g., bacteria, viruses, fungi). Students learn the fundamentals of the molecular interactions that occur between microbe and host that determine the outcome of an interaction between them. Intervention strategies used by humans (e.g., vaccination and antimicrobial therapy, and the corresponding microbial adaptive mechanisms) are also covered. R. Daum, Staff. Spring.
25307. Molecular Genetic Analysis of Bacteriophage. PQ: BIOS 20200. This course meets one of the requirements of the microbiology special-ization. Phage are the most abundant and fastest growing biological entities, and are involved in many natural microbiological processes. This course examines a series of bacteriophage that have been instrumental in our understanding of genetics and molecular biology, with an emphasis on their properties and the methods for which they are used in current and potential biological studies and in biotechnology. M. Casadaban. Spring.
25407. Organ Transplantation. PQ: BIOS 25256. This course presents biological, technical, ethical, and economic issues associated with organ transplantation. We sharply focus the immunologic knowledge from BIOS 25256 onto the biologic barriers to organ acceptance and the ultimate goal of immunologic tolerance. We also address principles of organ preservation and the mechanisms of ischemia/reperfusion injury. The technical aspects and physiology of organ transplantation (i.e., kidney, liver, heart, lung, pancreas, islet, intestinal) are covered. The social, economic, and ethical issues raised in transplantation (i.e., allografts, xenografts, living donation) are also discussed. A. Chong, J. Williams, M. Millis, R. Thistlethwaite, D. Cronin, M. Garfinkel, R. Harland, V. Jeevanandum. Winter, 2005.
25409. Immuno-logic: A Systems Approach. Computer programming background not required. Students do research on current issues in immunology such as the nature and the development of autoimmune diseases (including lupus and diabetes), the development of optimal organ transplantation strategies, the development of vaccines for viruses including HIV and influenza, and the significance and planning of HIV drug holidays, as well as student-derived projects. Experiments are carried out "in silico" using IMMSIM, which is a cellular automaton-based immune system simulation developed at IBM's research labs. Lectures provide background to these and other issues including principles of cellular automaton modeling taking a Darwinian approach to understanding the complexity of the immune system. Instructions on the use and application of IMMSIM are provided, as well as directions on how class research can be related to the broader field of computational biology. J. Quintans, M. Weigert. Spring.
25410. The BIO 2010 University of Chicago Initiative: Viruses as Probes of Cellular Functions. PQ: BIOS 25306 or 25210, and consent of instructor. Because this course is designed to involve students in original research projects in molecular biology and virology, the focus of individual projects varies every year. Lectures cover topics relevant to the particular research project as well as the techniques used in their experiments. Hands-on laboratories expose students to a variety of cutting-edge techniques, such as the use of DNA microarrays, the challenge of data analysis, and the use of Real Time PCR. Under faculty guidance, students are responsible for the experimental design, for the execution of experiments, and for the analysis of data. Additional time in lab may be required. B. Roizman, B. Fienschi. Spring. L.
26106. Quantitative Topics in Ecology. PQ: One quarter of calculus. This course focuses on mathematical techniques for solving problems in ecology. The goal is to construct mathematical models that can explain ecological patterns and make predictions about how these patterns might be altered by changes in the environment. We emphasize the identification of interesting biological puzzles and how to solve them using the appropriate mathematical tools. P. Amarasekare. Autumn.
26317. Molecular Mechanisms of Cell Signaling. (=CPHY 31900, NURB 31900) PQ: BIOS 20181-20183 or 20191-20193, and 20200. Cells in the body communicate with each other by a variety of extracellular signals (e.g., hormones, neurotransmitters) and processes such as vision and olfaction, as well as diseases such as cancer, all involve aspects of such signaling processes. The subject matter of this course considers molecular mechanism of the wide variety of intracellular mechanisms that, when activated, change cell behavior. Both general and specific aspects of intracellular signaling are covered in the course, with an emphasis on the structural basis of cell signaling. W.-J. Tang. Spring.
26400. Introduction to Bioinformatics. PQ: BIOS 20182 or 20192, or MATH 15100, or consent of instructor. This course introduces the concepts, purposes, tools, skills, and resources of bioinformatics. It includes a description of GenBank and other sequence databases; genetic and physical mapping databases; and structure databases. It also explains definitions such as homology, similarity, and gene families. Other topics include the basic principles and computational skills of comparative and phylogenetic analyses of DNA and protein sequence data, computer skills in database searching and information retrieval, predictive methods using DNA sequences, predictive methods using protein sequences, and comparative genomics. W. Li. Winter. L.
26401. Evolutionary Genomics. The exponentially expanding sequence databases, in consequence of the human genome project and other molecular studies, provide an opportunity to investigate the makeup of genes and genomes in evolutionary perspectives. This course is an introduction to a new field in biological sciences: the evolutionary analysis of genomic data of various organisms. It covers important concepts of evolution of genes and genomes, introduces major accomplishments in the field, and teaches basic technical skills such as computer programming and simulation necessary for the data analysis. This course focuses on training the student's ability to access and analyze available genomic databases to study questions of biological interest. M. Long, T. Nagylaki. Spring. L.
26402. Computational Biology. PQ: Third- or fourth-year standing; completion of the general education requirements in biological sciences or the AP 5 sequence; basic knowledge of differential equations and statistics; and consent of instructor. This course introduces students to concepts and techniques from physics, mathematics, and computer science that can aid the study of complex biological systems. We emphasize the analysis of intracellular pathways in terms of modular information processing units. Students model biological systems using analytical and computational methods. T. Emonet. Spring.
29000. Critical Thinking in Biology and Life. PQ: Consent of instructor. This course may be used as a topics course for students not majoring in biological sciences. How does one impose order on the vast quantity of claims and information that we are subjected to on a daily basis? How does one evaluate competing scientific explanations? How does one translate beliefs and emotions into action in the face of incomplete information and uncertain consequences? How does one incorporate new knowledge into an existing complicated system of beliefs? The goal of this course is to start developing a reasoning toolbox that students can use to address issues of practical importance as a person and citizen. Examples will focus on current issues in biology such as human diseases and genetic engineering. I. Pavlova. Spring.
Big Problems Courses
02370. Psychoneuroimmunology: Links between the Nervous and Immune Systems. (=BPRO 24200, PSYC 24150/34100) PQ: Third or fourth-year standing, and BIOS 20180s or 20190s. This course meets requirements for the biological sciences major. For course description, see Big Problems. M. McClintock, J. Quintans. Spring.
02800. Cultural Evolution and Dimensions of Globalization. (=BPRO 24000, CFSC 25000, HIPS 21500, LING 11200, NCDV 27500, PHIL 32600) PQ: BIOS 29286 or consent of instructor. This course does not meet requirements for the biological sciences major. For information on when course will be offered, call Margot Browning at 702-5657. The focus of this two-quarter sequence is on cultural evolution and the globalization of culture. Relevant disciplines are evolutionary genetics, epidemiology, demography, economics, communications, science and technology, anthropology, history, and political science. We discuss issues such as the spread of new diseases, rise of multinational corporations, free trade, popular culture, the Internet, English as an emerging world language, and extinction of languages and cultures. S. Mufwene, J. Sadock, W. Wimsatt, Staff.
02810. The Complex Problem of World Hunger. (=BPRO 24200, ENST 24800, SOSC 26900) PQ: Third- or fourth-year standing. This course does not meet requirements for the biological sciences major. Few of our policy makers are experts in economics, agronomy, food science, and molecular biology, yet all of these disciplines are essential for developing strategies to end world hunger. Choosing one country as a test case, we look in detail at the history, politics, governmental structure, population demographics, and agricultural challenges. We then study the theory of world markets, global trade, and microeconomics of developing nations as it applies to the problem of food deficit, as well as examine the promise and limitation of traditional breeding and biotechnology for improving food security. J. Malamy, A. Sanderson. Spring, 2005.
02927. Perspectives on Imaging. (=ARTH 26900/36900, BPRO 27000, CMST 27300/37300, HIPS 24801) This course does not meet requirements for the biological sciences major. This course explores technical, historical, artistic, and cultural aspects of imaging from the earliest attempts to enhance and capture visual stimuli through the medical imaging revolution of the twentieth century. Topics include the development of early optical instruments (e.g., microscopes, telescopes); the first recording of photographic images; the emergence of motion pictures; the development of image-transmission technologies (e.g., offset printing, television, the Internet); and the invention of means to visualize the invisible within the body through the use of X-rays, magnetic resonance, and ultrasound. B. Stafford, P. LaRiviere. Autumn, 2005.
Specialized Courses
These courses may not be counted toward the courses required for the major.
29000. Critical Thinking in Biology and Life. PQ: BIOS 10100 or 10110. This course is designed for students who are interested in improving reasoning abilities in all areas of their lives. The goal is to start developing a reasoning toolbox that can be used to address issues of practical importance as a person and citizen. Examples focus on current issues in biology such as human diseases and genetic engineering. This course require students to actively engage their minds and challenge themselves on this journey aboard the "spaceship of the mind" (as Carl Sagan put it). I. Pavlova. Spring.
29281. Introduction to Medical Ethics. (=HIPS 21400) PQ: Second-year standing or higher. This course does not meet requirements for the biological sciences major. This course explores the ethical issues raised by modern medicine. We begin with an introductory examination of the foundations of medical ethics. We also discuss the doctor-patient relationship: how it evolved since World War II and how it should evolve in the twenty-first century. We examine moral issues raised by human experimentation, organ transplantation, and the human genome project. H. Ross. Winter.
29283. Neurology and Kant's Theory of Mind. (=HIPS 28501) PQ: Third- or fourth-year standing. This course does not meet requirements for the biological sciences major. In this course we cover most of the first half of Kant's Critique of Pure Reason, which contains his theory of perception and cognition. Our goal is to grasp the distinctively Kantian level of abstraction that he called "transcendental." When this is understood, the critique is transformed from an object of misinterpretation and uninformed criticism into a text that speaks intelligibly, and even helpfully, to present-day cognitive neurobiology (though Kant was not primarily analyzing, nor, much less, doing, empirical physiology or psychology). We also read several original, landmark papers from the related scientific literature subsequent to Kant's time. S. Schulman. Autumn.
29286. Biological and Cultural Evolution. (=BPRO 23900, CHSS 37900, HIPS 23900, LING 11100, NCDV 27400, PHIL 22500/32500) PQ: Third or fourth-year standing or consent of instructor required; core background in genetics and evolution strongly recommended. This course does not meet requirements for the biological sciences major. For information on when course will be offered, call Margot Browning at 702-5657. This course draws on readings and examples from linguistics, evolutionary genetics, and the history and philosophy of science. We elaborate theory to understand and model cultural evolution, as well as to explore analogies, differences, and relations to biological evolution. We also consider basic biological, cultural, and linguistic topics and case studies from an evolutionary perspective. Time is spent both on what we do know, and on determining what we don't. W. Wimsatt, S. Mufwene. Spring, 2006.
29288. Genetics in an Evolutionary Perspective. (=CHSS 34210, HIPS 21401, PHIL 32201) PQ: Completion of the general education requirement for the biological sciences and prior course in pre-calculus mathematics. This course does not meet requirements for the biological sciences major. This course covers the historical development of theories of heredity and evolution, from before Darwin and Mendel, through the development of cytology and classical genetics, population genetics and neo-Darwinism to evolutionary developmental biology and "eco-evo-devo" and the relation between macro-evolution and micro-evolution. We also discuss disputes between current and historical applications in biology and the social sciences. This course includes computer simulations for historical and modern simpler models in population biology, as well as the strategy and tactics of mathematical model building. W. Wimsatt. Spring.
29291. The History of U.S. Public Health. (=HIPS 21701) This course does not meet requirements for the biological sciences major. This discussion-based course explores changes in public responsibility for health in the United States from 1800 to the later part of the twentieth century. Primary and secondary readings address how public health has responded to disease, knowledge of disease processes, social conditions, politics, and the medical profession. Topics include the public health response to epidemics, the sanitary movement, immigration concerns, public health research, private foundation initiatives, disease surveillance, vaccine policies, and risk factor epidemiology. D. Lauderdale. Spring.
29298. Current Issues in Medical Economics. (=HSTD 58301) PQ: Third- or fourth-year standing. This course does not meet requirements for the biological sciences major. This course uses case studies of a number of specific issues in health economics and policy to illustrate relevant analytic frameworks. Course includes lectures from faculty members in a number of different divisions and departments as well as lectures from non-faculty members. M. Koetting, L. Vinci, K. Patel. Spring.
29306. Evolutionary Processes. (=CHSS 34800, ECEV 31000, EVOL 31000, HIPS 20800) PQ: Consent of instructor. This course does not meet requirements for the biological sciences major. this course we examine evolutionary aspects of ecology, genetics, biochemistry, paleontology, development, philosophy, and related subjects through readings, essays, and discussions. L. Van Valen. Autumn.
29326. Introduction to Medical Physics and Medical Imaging. PQ: PHYS 23500. This course does not meet requirements for the biological sciences major. This course covers the interaction of radiation with matter and the exploitation of such interactions for medical imaging and cancer treatment. Topics in medical imaging include X-ray imaging and radionuclide imaging, as well as advanced technologies that provide three-dimensional images, including X-ray computed tomography (CT), single photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRI), and ultrasonic imaging. P. La Riviere, M. Giger, C. Pelizzari. Spring.
29405. Mathematical and Statistical Methods for Neuroscience I. (=CPNS 32000) PQ: College-level course in calculus required; some background in neurobiology recommended. This course meets requirements for the biological sciences major only for students specializing in neuroscience. This is the first course of a three-quarter sequence that introduces methods in applied mathematics and probability theory that are applicable to problems in neuroscience. It discusses ordinary differential equations and partial differential equations as well as linear algebra, and considers applications of dynamical systems theory to issues in neuro-science. J. Hunter. Autumn.
29406. Mathematical and Statistical Methods for Neuroscience II. PQ: BIOS 29405 or consent of instructor. This course meets requirements for the biological sciences major only for students specializing in neuroscience. This second course in the sequence deals with analysis of data obtained from physiological and imaging experiments using methods from signal processing and non-linear dynamics. Signal averaging, continuous and discrete Fourier methods, Laplace and z-transforms, basic properties of filters and applications of dynamical systems theory to physiological signals are considered. W. van Drongelen. Winter.
29407. Mathematical and Statistical Methods for Neuroscience III. (=CPNS 32200) PQ: BIOS 29405 and 29406, or consent of instructor. This course meets requirements for the biological sciences major only for students specializing in neuroscience. This third course in the sequence deals with applications of artificial neural nets and topics in mathematical probability and statistics to issues, such as neural coding, in neuroscience. Spring.
Independent Study and Research
00199. Undergraduate Research. PQ: Consent of research sponsor and the director of the honors program in biological sciences. Students are required to submit the College Reading and Research Course Form. This course is graded P/F. This course does not meet requirements for the biological sciences major. This course may be elected for up to three quarters. Students must submit a one-page summary of the research planned to their research sponsor and the director of the honors program before the Friday of the fifth week of the quarter in which they register. A detailed five- to ten-page report on the completed work must be submitted to the research sponsor and the director of the honors program before Friday of examination week. D. Nelson. Summer, Autumn, Winter, Spring.
00206. Readings in Biology. PQ: Consent of faculty sponsor. Students are required to submit the College Reading and Research Course Form. This course is graded P/F. This course does not meet requirements for the biological sciences major. Students may register for only one BIOS 00206 tutorial per quarter. Enrollment must be completed by the end of the second week of the quarter. This is a tutorial offering individually designed readings. Summer, Autumn, Winter, Spring.
00298. Undergraduate Research Seminar. PQ: Fourth-year standing and consent of the director of the honors program. Students will receive a letter grade and may count this course toward requirements for the biological sciences major. This seminar course is required of graduating students in the honors program. The honors thesis is revised during the year and submitted third week of Spring Quarter. Students also participate in a poster session early in Spring Quarter. D. Nelson. Spring.
00299. Advanced Research in the Biological Sciences. PQ: Fourth-year standing. Consent of research sponsor and the director of the honors program in biological sciences. Students are required to submit the College Reading and Research Course Form. This course is graded P/F. This course does not meet requirements for the biological sciences major. In the first quarter of registration students must submit a Supplementary Information Form to their research sponsor and to the director of the honors program. D. Nelson. Summer, Autumn, Winter, Spring.
Graduate-Level Courses
Many graduate-level courses in the Division of the Biological Sciences are open to qualified College students. Students should consult their advisers, the BSCD office, or the various departments and committees in the division to identify appropriate courses.